Bioquimica

PHARMACEUTICAL CALCULATIONS
* * * * * * * * * * * * * * * * * * * * 1 Kilogram = 1 Gram = 1 Milligram = 1 Microgram = 1 Milligrams = 1 Microgram = 1 Nanogram = 1 Grain = 1 Litre = 1 OZ = 16 OZ = 1 Pint = 1 Quart = 1 Gallon = 2.2 lbs = 1 Teaspoonful = 1 Tablespoonful = 1 Teacupful = 1 Wineglassful = 1 Tumblerful = 1000 1000 1000 0.001 0.001 10 -6 10 -9 65 1000 30 480 480 960 3840 1 5 15 120 60240 grams milligrams micrograms milligrams grams grams grams milligrams cc cc cc = 1 Pint cc cc = 2 Pints cc = 4 Quarts = 8 Pints kg cc cc cc cc cc

* *

Density Proof Gallon

= =

Weight / volume gallon x % V/V strength 50% V/V gallon x proof strength 100 proof gram atomic weight valence equivalent weight 1000

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Proof Gallon

=

*

Equivalent wt

=

*

Milliequivalent =*

Young’s Rule

=

Child dose Child dose Child dose

=

Age in year Age + 12 Age in year x adult dose 12 Age in month x adult dose 150

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Drilling’s rule

=

=

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Fried’s rule

=

=

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Clark’s rule

=

Child dose

=

Weight in lb x adult dose 150

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Child dose

=

Body surface area of child x adult dose Body surface area of adult Body surfacearea of child x adult dose 173 M 2

*

Child dose

=

TPN CALCULATIONS:
* * * * * * * * * Each gram of I.V. dextrose provides Each gram of anhydrous dextrose provides Each gram of fats provides MCT provides Each gram of protein provides Each gram of glycerol provides 1 cc of alcohol provides 1 cc of 10% lipid emulsion provides 1 cc of 20% lipid emulsion provides = = = = = = = = = 3.4Kcal/gm 4 Kcal/gm 9 Kcal/gm 8.3 Kcal/gm 4 Kcal/gm 4.3 Kcal/gm 5.6 Kcal 1.1 Kcal 2 Kcal

1.
a. b. c. d.

How many grams of Dextrose is present in a 500cc D5W solution ? 40 grams 5 grams 25 grams 10 grams

a. b. c. d.

32.5 mg 3.25 gm 3.5 mcg 0.325 mg

7.

2.
a. b. c. d.

How many grams of drug is required to dispense 1 pint of 1 in 25 solution ? 3.4 grams 19.2 grams 22.3 grams 14.5 gramsIf 1 teaspoonful of Thioridazine intense solution (30mg/cc) is diluted up to 480cc mark with plain water, what would be the final strength of solution in mg/ml ? a. b. c. d. 0.52 mg/cc 0.31mg/cc 3.1 mg/cc 2.5 mg/cc

8. 3.
a. b. c. d. How much lidocaine is present in a 1 : 1000, 30cc solution of lidocaine ? 30 mg 30 gm 30 mcg 3 gm

If 60 gram of 1% Hydrocortisone is mixed with 80 gram of2.5% Hydrocortisone, what is the % w/w of hydrocortisone in final mixture ? a. b. c. d. 2.25 % 3.15 % 1.85 % 4.35 %

4.
a. b. c. d.

How much atropine is required to dispense 1 quart of 1 in 100 solution ? 18 gm 9.6 mg 9.6 gm 18 mcg

9.
a. b. c. d.

Find out the ratio of an ionize drug to unionize at pH = 7. The PKa value of drug is 5. 100 10 -2 0.001 1000

5.

How many cc of 75%alcohol should mix with 1000cc of 10% alcohol solution to prepare 500cc of 30% alcohol ? a. b. c. d. 153.84 cc 456.34 cc 212.5 cc 121.12 cc

10.
a. b. c. d.

An adult dose of drug is 500mg, what is the dose for a 2-year old child ? (Young rule) 110 mg 41.52 mg 63.20 mg 71.42 mg

6.

How many milligrams are equal to 1/ 200 grain of nitroglycerine ?

11.

If an adult dose of drug is 750mg,what is the dose for child weighing 20 lbs ?

a. b. c. d.

250 mg 150 mg 50 mg 100 mg

a. b. c. d.

25.53 mEq 15.67 mEq 38.46 mEq 45.20 mEq

12.

If an adult dose of drug is 100mg, what would be dose for a child that has a body surface area 0.9 m2 ? a. b. c. d. 1.25 mg 0.52 mg 0.60 mg 2.3 mg

17.

How many milliequivalents of ferrous are present in 5 gr of ferrous sulfate? [ MW =152 gm/mole] a. b. c. d. 3.56 mEq 2.56 mEq 1.25 mEq 4.27 mEq

13.

If therapeutic dose of drug is 10mg/kg/ day, how many 250mg/100cc ready-infusionsbags should be filled ? Patient’s weight is 156 lbs. a. b. c. d. 3 bags 1 bags 2 bags 8 bags

18.
a. b. c. d.

What is the half-life of drug that has rate constant 0.067 days -1 ? [ First order kinetic] 12.11 days 5.56 days 10.34 days 3.25...