Hipotiroidismo

Prevalence of Congenital Hypothyroidism−−Current Trends and Future Directions: Workshop Summary Richard S. Olney, Scott D. Grosse and Robert F. Vogt, Jr Pediatrics 2010;125;S31 DOI: 10.1542/peds.2009-1975C

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PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication, it has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois, 60007. Copyright © 2010 by the American Academy of Pediatrics. All rights reserved. Print ISSN:0031-4005. Online ISSN: 1098-4275.

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SUPPLEMENT ARTICLE

Prevalence of Congenital Hypothyroidism—Current Trends and Future Directions: Workshop Summary
AUTHORS: Richard S. Olney, MD, MPH,a Scott D. Grosse, PhD,a and Robert F. Vogt Jr, PhDb
National Center on Birth Defects and Developmental Disabilities and bNationalCenter for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia KEY WORDS congenital hypothyroidism, neonatal screening, epidemiology, public health, conferences ABBREVIATIONS CH—primary congenital hypothyroidism CDC—Centers for Disease Control and Prevention T4 —thyroxine TSH—thyrotropin The findings and conclusions in this article are those of the authors and do notnecessarily represent the official position of the Centers for Disease Control and Prevention. www.pediatrics.org/cgi/doi/10.1542/peds.2009-1975C doi:10.1542/peds.2009-1975C Accepted for publication Jan 22, 2010 Address correspondence to Richard S. Olney, MD, MPH, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Rd, MailstopE-86, Atlanta, GA 30333. E-mail: rolney@cdc.gov PEDIATRICS (ISSN Numbers: Print, 0031-4005; Online, 1098-4275). Copyright © 2010 by the American Academy of Pediatrics FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
a

abstract
In response to published newborn-screening data that have shown an increase in the incidence(birth prevalence) rate of primary congenital hypothyroidism (CH) in the United States, a workshop was held in Atlanta, Georgia, on February 27 and 28, 2008, to examine this issue. Topics of the meeting included pathophysiology, medical management, and follow-up of CH; transient hypothyroidism (etiology, clinical implications, management, and changes in prevalence); risk factors for CH; laboratoryapproaches to newborn screening for CH; state-specific evaluations of trends in incidence rates of CH; and concluding discussions on future directions to resolve outstanding issues. Through presentations and discussion, gaps in knowledge were identified, such as the lack of consistent definitions for CH and transient hypothyroidism and the effects of preventable risk factors on incidence rates of CH.One outcome of the meeting was a series of accompanying articles that examined (1) trends in the incidence rates of CH in individual states and nationally, (2) effects of newborn-screening practices on CHincidence rates, (3) the contribution of transient hypothyroidism to CH-incidence rates, and (4) future research directions. In this summary, we briefly touch on the topics of these articles andexamine highlights of other presentations from the workshop that illuminated the secular trends in reported CH-incidence rates in the United States. Pediatrics 2010;125:S31–S36

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PEDIATRICS Volume 125, Supplement 2, May 2010

S31

In 2007, Harris and Pass1 published newborn-screening data from New York and the United...