Kdigo De Gn 2012

Summary of Recommendation Statements
Kidney International Supplements (2012) 2, 143–153; doi:10.1038/kisup.2012.13
Chapter 3: Steroid-sensitive nephrotic syndrome in
children
3.1: Treatment ofthe initial episode of SSNS
3.1.1: We recommend that corticosteroid therapy (prednisone or prednisolone)* be given for at least 12 weeks. (1B)3.1.1.1: We recommend that oral prednisone be administeredas a single daily dose (1B) starting at 60 mg/m2/dor 2 mg/kg/d to a maximum 60 mg/d. (1D)
3.1.1.2: We recommend that daily oral prednisone be given for 4–6 weeks (1C) followed byalternate-daymedication as a single daily dose starting at 40 mg/m2 or 1.5 mg/kg (maximum 40 mg on alternatedays) (1D) and continued for 2–5 months with tapering of the dose. (1B)
3.2: Treatment of relapsing SSNS withcorticosteroids
3.2.1:
3.2.2:
Corticosteroid therapy for children with infrequent relapses of SSNS:
3.2.1.1: We suggest that infrequent relapses of SSNS in children be treated with a single-dailydose ofprednisone 60 mg/m2 or 2 mg/kg (maximum of 60 mg/d) until the child has been in completeremission for at least 3 days. (2D)
3.2.1.2: We suggest that, after achieving complete remission,children be given prednisone as a single dose onalternate days (40 mg/m2 per dose or 1.5 mg/kg per dose: maximum 40 mg on alternate days) for atleast 4 weeks. (2C)
Corticosteroid therapy for frequentlyrelapsing (FR) and steroid-dependent (SD) SSNS:
3.2.2.1: We suggest that relapses in children with FR or SD SSNS be treated with daily prednisone until thechild has been in remission for at least 3 days,followed by alternate-day prednisone for at least3 months. (2C)
3.2.2.2: We suggest that prednisone be given on alternate days in the lowest dose to maintain remissionwithout major adverse effectsin children with FR and SD SSNS. (2D)
3.2.2.3: We suggest that daily prednisone at the lowest dose be given to maintain remission without majoradverse effects in children with SD SSNS where...