La Maestria Del Amor
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Publicado: 10 de junio de 2012
Nature | News
Cancer drugs affect mouse genomes for generations
DNA mutations continue to accumulate in offspring of treated mice.
Heidi Ledford
30 January 2012
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Three common chemotherapy drugs causeDNA mutations not only in mice that receive treatment, but also in their offspring, according to a study published today in the Proceedings of the National Academy of Sciences USA1.
The results suggestthat the genome in treated mice became destabilized yielding new mutations long after exposure to the drugs has ceased. A similar phenomenon has been observed in mice exposed to radiation.
Genomicdamage can be seen in the offspring of mice who have received chemotherapy drugs.
PAUL WOOTTON/SCIENCE PHOTO LIBRARY
The work emphasizes the importance of looking at the effects of chemotherapy notonly on recipients, but also on their descendants. But Yuri Dubrova, a geneticist at the University of Leicester, UK, who led the study, cautions against extrapolating the results of this study tohumans. Most adults treated for cancer are either too old to have children or become sterile from the treatment. “So we’re talking about one group only: childhood cancer survivors,” says Dubrova.
Onerecent study found no significant impact of radiation or chemotherapy on the rate of birth defects in 4,699 children of childhood cancer survivors2.
Furthermore, children who are treated for cancerwill not have children of their own for years or decades afterwards. Mice only live about two years, and the ones in Dubrova’s study reproduced a few months after their exposure to the drugs. “I wouldbe very careful in interpreting this data,” Dubrova says.
Genomic stability
Genome instability has intrigued Dubrova for more than a decade. Dubrova and his colleagues were studying the effects of...
Cancer drugs affect mouse genomes for generations
DNA mutations continue to accumulate in offspring of treated mice.
Heidi Ledford
30 January 2012
Article tools
EmailRights and Permissions
Share/bookmark
6. Connotea
7. Facebook
8. Delicious
9. Twitter
10. Digg
11. Friendfeed
Three common chemotherapy drugs causeDNA mutations not only in mice that receive treatment, but also in their offspring, according to a study published today in the Proceedings of the National Academy of Sciences USA1.
The results suggestthat the genome in treated mice became destabilized yielding new mutations long after exposure to the drugs has ceased. A similar phenomenon has been observed in mice exposed to radiation.
Genomicdamage can be seen in the offspring of mice who have received chemotherapy drugs.
PAUL WOOTTON/SCIENCE PHOTO LIBRARY
The work emphasizes the importance of looking at the effects of chemotherapy notonly on recipients, but also on their descendants. But Yuri Dubrova, a geneticist at the University of Leicester, UK, who led the study, cautions against extrapolating the results of this study tohumans. Most adults treated for cancer are either too old to have children or become sterile from the treatment. “So we’re talking about one group only: childhood cancer survivors,” says Dubrova.
Onerecent study found no significant impact of radiation or chemotherapy on the rate of birth defects in 4,699 children of childhood cancer survivors2.
Furthermore, children who are treated for cancerwill not have children of their own for years or decades afterwards. Mice only live about two years, and the ones in Dubrova’s study reproduced a few months after their exposure to the drugs. “I wouldbe very careful in interpreting this data,” Dubrova says.
Genomic stability
Genome instability has intrigued Dubrova for more than a decade. Dubrova and his colleagues were studying the effects of...
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