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VALDÉS, Marisela;GARRIDO, Gabino Tendencias en las investigaciones y publicaciones sobre las interacciones hierbafármacos Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, Vol. 7, Núm. 6, sin mes, 2008, pp. 345-358 Sociedad Latinoamericana deFitoquímica Chile
Disponible en: http://redalyc.uaemex.mx/src/inicio/ArtPdfRed.jsp?iCve=85611255006

Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas ISSN (Versión impresa): 0717-7917 blacpma_editorial@hotmail.com Sociedad Latinoamericana de Fitoquímica Chile

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© 2008 Los Autores Derechos de Publicación © 2008 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 7 (6), 345 - 358 BLACPMA ISSN 0717 7917 Artículo Original | Original Article

Especial sobre Interacción de Productos Naturales y Fármacos / Special Issue on Natural Products and DrugInteractions

Tendencias en las investigaciones y publicaciones sobre las interacciones hierba-fármacos
[Trends in researching and reporting on herbal-drug interactions]
Marisela VALDÉSa , Gabino GARRIDOb
a

Consultoría BioMundi, calle 200, No. 192; bCentro de Química Farmacéutica, 200 y 21, Atabey, Playa. Ciudad de La Habana, Cuba.
*Contacto: e-mail: marisela@biomundi.inf.cu,gabino.garrido@gmail.com Recibido Septiembre 18, 2008; Aceptado Noviembre 8, 2008; Published Online 25 November 2008

Abstract There is a lack of basic knowledge about the affirmation that herbs, vitamins, and other dietary supplements may augment or antagonize the actions of prescription and nonprescription drugs. This event should be taking account as to the indications for use and safety of herbal medicinesregarding the possibility of herbal-drug interactions. The objectives of this study were to review the literature for evidence and tendencies on the use, safety and pharmacology of herbal-drug interactions. To do it was searched the PubMed electronic database papers regarding to “herbal-drug interactions” until December 2007 and compiled data according to the grade of evidence found. It was compiled atotal of 413 papers related with the approached topic. The drugs more studied were warfarin, anti-neoplastic agents and digoxin and the herbals were hypericum, ginkgo, panax, kava, garlic, valerian and tea. The major investigations were executed on in vitro studies, principally on cytochrome P450 and P-glycoprotein. On the in vivo pre-clinical investigation; it was researched that the major papersused rats, mice, rabbits, and others. The countries with more publications were USA, Canada, United Kingdom, Japan, Germany, Australia, and Italy; the principal authors and Institutions were also from these countries. There was an increase in the published articles from 1999 reaching the maximal production in 2006 (74 papers). The journal with the major number of papers was Br J Clin Pharmacol. Thetype of article more written was the Review and the English was the language more used in these papers. There is an obvious interest regarding the herbal-drug interactions manifested in the increasing of the number of paper published about this topic. These investigations are not sufficient if we taking account the herbal medicine is one of most popular choices of complementary therapies and itcould induce interactions with the conventional medicines translated in a deficient treatment or adverse reactions that conduce to an erroneous therapy. It is important to recognize that there are not papers from Latin-American & Caribbean region related with herbal-drug interactions.
Keywords Trend, Herbal therapy, Herbal-drug interaction, Cytochrome P-450, Glycoprotein P, Metabolism....