Amoebic Dysentery

Azitromycin
Azithromycin blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA-dependent protein synthesis at the chain elongation step.Absorption: Reduced by food (capsule formulation); peak plasma concentrations after 2-3 hr.
Distribution: Extensive into the tissues (concentrations higher than those in blood), WBC (high concentrations), CSF(small amounts).
Metabolism: Liver (demethylation).
Excretion: Via the bile (as unchanged drug and metabolites); via the urine (6% of the dose). Elimination half-life: about 68 hr.
Amoxicillininhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesisresulting in bacterial lysis.
Absorption: Rapidly and completely absorbed from the GI tract with peak plasma concentrations after 1-2 hr (oral). Not inactivated by gastric acid and presence of food doesnot impair absorption.
Distribution: Widely distributed, CSF (small concentrations except when the meninges are inflamed), bile (high concentrations); crosses the placenta and enters the breast milk(small amounts). Protein-binding: 20%.
Metabolism: Converted to a limited extent to penicilloic acid.
Excretion: Via the urine within 6 hr by glomerular filtration and tubular secretion (aspenicilloic acid and 60% unchanged drug); via the faeces. May be removed by haemodialysis; 1-1.5 hr (elimination half-life).
Piperacillin inhibit septum and cell wall synthesis and has an antimicrobialactivity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against Garm-positive organisms eg, E. faecalis and B. fragilis.
Absorption: Not absorbedwhen given orally. IM: well absorbed with peak plasma concentrations after 30-50 min.
Distribution: Widely distributed into body tissues and fluids, CSF (small amounts except when the meninges are...