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Ejaculation Disorders
Ejaculation—The Long and Short of It
Reviewed by Jacob Rajfer, MD
Department of Urology, University of California at Los Angeles, Los Angeles, CA

[RevUrol. 2009;11(1):41]
© 2009 MedReviews®, LLC

function when taken 1 to 2 hours prior to sexual activity.1 To this end, Salem and colleagues recently published a report on their single-blind,placebo-controlled, crossover study on 60 patients with documented early or premature ejaculation using 25 mg of tramadol. They showed that the drug improved intravaginal ejaculation latency time by more than 5minutes. Based on their observations, the authors concluded that 25 mg of tramadol taken orally 1 to 2 hours prior to sexual activity should replace SSRIs as the standard first-line treatment of menwith early or premature ejaculation.
1. Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled,fixed-dose, randomized study. J Clin Psychopharmacol. 2006;26:27-31.

Tramadol HCL Has Promise in On-Demand Use to Treat Premature Ejaculation
Salem EA, Wilson SK, Bissada NK, et al.
J Sex Med.2008;5:188-193.

uring the past decade, the majority of investigative studies related to sexual dysfunction have revolved around erectile dysfunction (ED). Very little attention has been paid to one of thestepsisters of ED, disorders of ejaculation. This is surprising because the only sexual disorder more common than ED is premature ejaculation. It is estimated that about 33% of men complain of prematureor early ejaculation and, unlike ED, it is not age related— there is a high prevalence regardless of age. Although the mechanisms involved in the ejaculatory process are well known, what causes a manto have an early ejaculation response remains a mystery. Some have hypothesized that because so many men have this physiologic complaint, early ejaculation may not be a disorder at all and may...
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