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NEW MICROBIOLOGICA, 34, 109-146, 2011

Italian Guidelines for the Use of Antiretroviral
Agents and the Diagnostic-clinical Management
of HIV-1 Infected Persons
Andrea Antinori1, Simone Marcotullio2 Adriana Ammassari1, Massimo Andreoni3,
Gioacchino Angarano4, Giampiero Carosi5, Paola Cinque6, Antonella d’Arminio Monforte7,
Giovanni Di Perri8, Barbara Ensoli9, Enrico Ferrazzi10, MassimoGalli10, Claudio Mastroianni11,
Alberto Matteelli5, Francesco Mazzotta12, Mauro Moroni10, Giorgio Palù13, Massimo Puoti14,
Vincenzo Puro1, Giuliano Rizzardini15, Evangelista Sagnelli16, Fredy Suter17, Stefano Vella18,
Adriano Lazzarin6 for the Italian HIV Guidelines Working Group*
1National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy;
Onlus Foundation, Rome, Italy;3University of Tor Vergata, Rome, Italy; 4University of Bari, Bari, Italy;
5University of Brescia, Brescia, Italy; 6San Raffaele Scientific Institute, Milan, Italy;
7San Paolo Hospital, University of Milan, Milan, Italy; 8University of Turin, Turin, Italy;
9Istituto Superiore di Sanità, National AIDS Centre, Rome, Italy; 10University of Milan, Milan, Italy;
11S.M. Goretti Hospital, La SapienzaUniversity, Polo Pontino, Latina, Italy; 12S. M. Annunziata Hospital, Florence, Italy;
13University of Padua, Padua, Italy; 14Niguarda Hospital, Milan, Italy; 15L. Sacco Hospital, Milan, Italy;
16University of Naples, Naples, Italy; 17Ospedali Riuniti di Bergamo, Bergamo, Italy;
18Istituto Superiore di Sanità, Department of Therapeutic Research and Medicine Evaluation, Rome, Italy
2Nadir

*Thecomplete members of the Italian HIV Guidelines Working Group are listed in the acknowledgment session.
The final version was published in July 15, 2010 (web link:
http://www.salute.gov.it/imgs/C_17_pubblicazioni_1301_allegato.pdf).
Authorized by the Ministry of Health and Istituto Superiore di Sanità, National AIDS Centre. In collaboration with the National
AIDS Commission and the Conference ofAssociations for the War Against AIDS, Ministry of Health, and with the Italian Society
of Infectious and Tropical Diseases (SIMIT).

INTRODUCTION
This short version complies with the intention expressed in the methodological introduction to the
full text Italian Guidelines for the use of antiretroviral drugs and the diagnostic-clinical management
of people with HIV-1 infection. Bydefinition, this
version should not be considered completely exhaustive with respect to the full text version of
the Guidelines, that are available at web site:
http://www.salute.gov.it/imgs/C_17_pubblicazioni_1301_allegato.pdf.

Corresponding author
Adriano Lazzarin, MD
San Raffaele Scientific Institute
Department of Infectious Diseases
Via Stamira D’Ancona 20 - 20127 Milano, Italy
E-mail:adriano.lazzarin@hsr.it

The aim of this version is simply to render certain
concepts expressed in the document more usable,
by specific circulation in booklet form, inviting
the reader to refer to the extended version for further information and full details.
It was decided not to discuss in toto in this version certain fundamental parts of the extended
versions such as the populationsrequiring special attention (elderly, women, immigrants, children), the conditions requiring special attention
(drug and/or alcohol addiction, detention) or the
situations requiring special attention (transplants).
For all these populations, conditions or situations,
it should be referred at the full text version of the
Guidelines.
Lastly, it was decided to refer the reader to the
extended versionfor all bibliographic citations,
except for the essential references cited at the end
of this version.

Italian Guidelines for the use of antiretroviral drugs and the diagnostic-clinical management of people with HIV-1 infection

110

TABLE 1 - Degree of recommendation and level of evidence
Degree of recommendation

A

Highly recommended.

B

Moderately recommended.

C...