Materiales De Regeneracion Osea

ORIGINAL ARTICLE

http://dx.doi.org/10.5125/jkaoms.2012.38.1.2

Clinical application of auto-tooth bone graft material
Sung-Min Park1, In-Woong Um2, Young-Kyun Kim3, Kyung-Wook Kim1 1 Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, 2 Chief Technology Officer, R&D Director, Korea Tooth Bank, Seoul, 3Seoul National University Bundang Hospital,Seongnam, Korea

Abstract (J Korean Assoc Oral Maxillofac Surg 2012;38:2-8)
Introduction: Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinductioncapacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission. Materials and Methods: Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillarysinus augmentation, and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011. Results: Clinical assessment: Among the 250 patients of auto-tooth bone graft,clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histologicalassessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated. Conclusion: Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.

Key words:Auto-tooth bone, Osteoconduction, Osteoinduction [paper submitted 2012. 1. 13 / revised 2012. 2. 6 / accepted 2012. 2. 6]

I. Introduction
Nowadays, various bone graft materials are developed due to advanced bio­graft material development technologies; as a result, dento alveolar surgery can handle difficult osseous defects with various methods in the placement of implant, periodontal surgery, andmaxillofacial surgery. The auto­ tooth bone graft material is a system that treats patients by manufacturing bone graft material from their own extracted teeth. It has first been introduced by the Korea Tooth Bank
Kyung-Wook Kim
Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 7-1, Sinbu-dong, Cheonan 330-716, Korea TEL: +82-41-550-1993 FAX: +82-41-551-8988E-mail: kkwoms@dku.edu
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R&D Center, and has satisfied many clinicians and patients for itsosteoconduction as well as osteoinduction capacity. Auto­tooth bone graft material consists of 55% inorganic and 45% organic substances. Among the inorganic sub­ stances, hydroxyapatite (HA) has the characteristics of combining and dissociating calcium and phosphate as those of bone. Organic substances include the bone morphogenetic protein (BMP) and proteins with osteoinduction capacity as well as...