Pcr Como Predictor De Ateromas

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Nutr Metab Cardiovasc Dis. Author manuscript; available in PMC 2012 October 1.
Published in final edited form as: Nutr Metab Cardiovasc Dis. 2011 October ; 21(10): 776–782. doi:10.1016/j.numecd.2010.02.003.

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High sensitivity C-reactive protein predicts the development of newcarotid artery plaques in older persons
R Molino-Lova, MD(1),(2), C Macchi, MD(1),(3), AM Gori, BSc(1),(4), R Marcucci, MD(4), P Polcaro, MD(1), F Cecchi, MD(1), F Lauretani, MD(5), S Bandinelli, MD(6), R Abbate, MD(3), E Beghi, MD(7), JM Guralnik, MD, PhD(8), and L Ferrucci, MD, PhD(9) (1) Dept. Cardiovascular Rehabilitation, Don Gnocchi Foundation, Florence, Italy
(2) (3) (4)

Dept.Cardiopulmonary Rehabilitation, Don Gnocchi Foundation, Massa, Italy Dept of Medical and Surgical Critical Care, University of Florence, Florence, Italy

Dept of Medical and Surgical Critical Care, University of Florence, Florence, Italy Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies (DeNOTHE)
(5) (6) (7)

Tuscany HealthRegional Agency, Florence, Italy Geriatric Rehabilitation Unit, ASF, Florence, Italy

Laboratory of Neurological Disorders, Institute for Pharmacological Research Mario Negri, Milan, Italy
(8)

Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
(9)

Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging,Baltimore, Maryland, USA

Abstract
Background—Previous studies have shown that increased levels of C-reactive protein (CRP) predict cardiovascular events, including stroke, myocardial infarction and death from cardiovascular causes. Previous studies have also shown that increased levels of CRP are strong predictors of the progression of pre-existing carotid artery plaques. However, whether CRP isinvolved in the development of new plaques, that may or may not be associated with clinical events, in subjects with clean carotid arteries has been scarcely investigated Methods—486 “InCHIANTI” Study participants (200 men and 286 women, 72% aged 65 years and over) free from carotid artery plaques at baseline, also underwent carotid artery scan three years later. We tested the association ofbaseline characteristics, cardiovascular risk factors and inflammatory markers with the development of new carotid artery plaques. Results—Older participants were significantly more likely to develop new plaques. Independent of age, the relative risks of developing new plaques associated with heavy smoking and family

Address for correspondence: Raffaele Molino-Lova, MD, Dept. CardiovascularRehabilitation, Don Gnocchi Foundation, Via Imprunetana 124 - 50020 Pozzolatico, Florence. Italy. raffmoli@tin.it rmolino@dongnocchi.it, Phone: +39 055 2601 024 - Fax: +39 055 2601 256. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergocopyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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history of atherosclerosis were 1.7 (95%CI 1.5-1.9) and 1.9 (95%CI 1.2-3.1), respectively.Participants with high (>3 microg/mL) and moderate (≥1 and ≤3 microg/mL) CRP levels had a relative risk of 2.2 (95%CI 1.9-2.6) and 1.9 (95%CI 1.6-2.3) respectively, when compared with subjects with low ( 4 hours/week or
Nutr Metab Cardiovasc Dis. Author manuscript; available in PMC 2012 October 1.

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Molino-Lova et...