Receptores ah (aryl hydrocarbon receptor)

AhR
Un receptor para los hidrocarburos arómaticos es una proteína intracelular a la cual se enlazan compuestos arómaticos halogenados --bifenilos policlorados y dioxinas incluídos--. El complejo formado se moviliza al nucleo de la célula, dentro del cuál controla la iniciación de una serie de procesos de biotransformación para la excreta de hidrocarburos. Este enlace tambien puede producir lasíntesis de otras proteínas, algunas de las cuales pueden interferir adversamente con el crecimiento y la diferenciación celular. Los receptores Ah tienen afinidad por hidrocarburos aromáticos halogenados, incluyendo dioxinas y bifenilos policlorados (PCBs), lo cual puede causar cambios en la expresión genética, afectar el desarrollo, morfología y funcionalidad celular, esta es la razón de queestos hidrocarburos sean potenciales cancerígenos y/o teratogénicos.


Algunas referencias para profesionales de la salud:

Rier SE, Martin DC, Bowman RE, et. al. Endometriosis in Rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund Appl Toxicol 21:433-441, 1993.
Pluim JJ, deVilder J, Olie K, et. al. Effects of pre- and postnatalexposure to chlorinated dioxins and furans on human neonatal thyroid concentrations. Environ Health Perspect 101:504-508, 1993.
Nessel CS, Gallo MA. Dioxins and related compounds. In: Environmental Toxicants, Ed. Lippmann M. Van Nostrand Reinhold, New York, 1992.
Sweeney MH, Hornung RW, Wall DK, et.al. Prevalence of diabetes and elevated serum glucose levels in workers exposed to2,3,7,8-tetrachloro-p-dioxin. Organohalogens 11:225-226, 1992.
Carcinogenicity of TCDD in animals. Draft dioxin reassessment. EPA/600/AP-92/001f, 1992.
Huff J. Dioxins and mammalian carcinogenesis. In: Schecter A. ed. Dioxins and health. New York: Plenum Press, 1994.
Hardell L, Sandstrom A. Case-control study.: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br JCancer 39:711-717, 1979.
Erikkson M, Hardell L, Berg NO, et. al. Soft-tissue sarcomas and exposure to chemical substances: A case-referent study. Br J Ind Med 38: 27-33, 1981.
Hardell L, Erikkson M, Lenner P, et. al. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols, and phenoxy acids: a case-control study. Br J Cancer 43: 169-176 1981.
Hardell L,Johansson B, Axelson O. Epidemiological study of nasal and nasopharyngeal cancer and their relation to phenoxy acid or chlorophenol exposure. Am J Ind Med 3: 247-257, 1982.
Fingerhut MA, Halperin WE, Marlow DA, et. al. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med 324:212-218, 1991.
Smith AH, Fisher DO, Giles HJ, et. al. The New Zealand softtissue sarcoma case-control study: Interview findings concerning phenoxyacetic acid exposure. Chemosphere12:565-571.
Kang HK, Weatherbee L, Breslin PP, et.al. Soft tissue sarcomas and military service in Vietnam: A case comparison group analysis of hospital patients. J Occup Med 28: 1215-1218, 1986.
Thigpen JE, Faith RE, McConnell EE, Moore JA. Increased susceptibility to bacterialinfection as a sequela of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Infect Immun 12:1319-1324.
House RV, Lauer RD, Murray MJ, et.al. Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Envi on Health 31:203-215, 1990.
Tucker AN, Vore SJ, Luster MI. Suppression of B cell differentiation by2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 29:372-377, 1986.
Luster MI, Boorman GA, Dean JH. Examination of bone marrow, immunologic parameters, and host susceptibility following pre- and post-natal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). nt J Immunopharmacol 2:301-310, 1980.
Murray FJ, Smith FA, Nitschke GG, et.al. Three-generation reproduction study of rats...