Resena Al Articulo Trl 4 Y Trl 9 Y Su Expresion En Diferentes Tipos De Rinitis

UNIVERSIDAD DE GUAYAQUIL

Nombre: Andrés Cuenca Orellana
Tercer año grupo 20
Cátedra: Inmunología

TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis.

AbstractBackground. Toll-like receptors (TLRs) represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive immune responses. Aim. The purpose of this study was toinvestigate the expression of TLR4 and TLR9 in the normal nasal mucosa and in the mucosa of subjects with different phenotypes of rhinitis. Methodology. A confocal analysis of TLR4 and TLR9 (co)expressionwas carried out on biopsies from the inferior turbinate obtained from 4 patients affected by persistent allergic rhinitis, 8 patients with chronic rhino-sinusitis, and 6 patients with vasomotorrhinitis The results were compared with those of specimens obtained from 4 subjects undergoing nasal surgery, but with signs of nasal inflammation. Results. TLR4 and TLR9 were expressed in the healthy nasalmucosa; TLR4 and TLR9 expression was significantly decreased in allergic rhinitis. TLR4 was over expressed in the epithelium of chronic rhino-sinusitis. Both TLRs were co-expressed in thesub-epithelial infiltrate of chronic and vasomotor rhinitis, even though this expression was higher in the former compared with the latter. Conclusions. This study indicates that TLR4 and TLR9 show a differentpattern of expression in different phenotypes of rhinitis, possibly related to the type and severity of the disease.

¿Que hicieron los investigadores?
Tratan de mostrar la expresión de los TLR4 y9en pacientes con rinitis de diferentes clases en la mucosa de la nariz
¿Como lo hicieron?
Se tomaron muestras mediante biopsias de 6 pacientes rinitis vaso motora 4 con rinitis alérgica 8 conrino-sinusitis crónica que se compararon con 4 pacientes que se habrían sometido a cirugía nasal
¿Que obtuvieron?
Al comparar las muestras de ambos paciente se determino que existía un gran...