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Comparative Effectiveness Review Number 26

Therapies for Children With Autism Spectrum Disorders


Comparative Effectiveness Review
Number 26

Therapies for Children With Autism Spectrum Disorders
Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov

Contract No. 290-2007-10065-IPrepared by: Vanderbilt Evidence-based Practice Center Nashville, TN Investigators: Zachary Warren, Ph.D. Jeremy Veenstra-VanderWeele, M.D. Wendy Stone, Ph.D. Jennifer L. Bruzek, Ph.D. Allison S. Nahmias, M.Ed. Jennifer H. Foss-Feig, M.A. Rebecca N. Jerome, M.L.I.S., M.P.H. Shanthi Krishnaswami, M.B.B.S., M.P.H. Nila A. Sathe, M.A., M.L.I.S. Allison M. Glasser, B.A. Tanya Surawicz, M.P.H. Melissa L.McPheeters, Ph.D., M.P.H.

AHRQ Publication No. 11-EHC029-EF April 2011

This report is based on research conducted by the Vanderbilt Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2007-10065-I). The findings and conclusions in this document are those of the author(s), who are responsible for itscontents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—makewell-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources andcircumstances presented by individual patients. This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied. This document is in the public domain andmay be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders. None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. Suggested citation: Warren Z, Veenstra-VanderWeele J, Stone W, Bruzek JL, NahmiasAS, Foss-Feig JH, Jerome RN, Krishnaswami S, Sathe NA, Glasser AM, Surawicz T, McPheeters ML. Therapies for Children With Autism Spectrum Disorders. Comparative Effectiveness Review No. 26. (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I.) AHRQ Publication No. 11-EHC029-EF. Rockville, MD: Agency for Healthcare Research and Quality. April 2011.Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm.

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Preface
The Agency for Healthcare Research and Quality (AHRQ) conducts the Effective Health Care Program as part of its mission to organize knowledge and make it available to inform decisions about health care. As part of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, Congress directed AHRQ to conductand support research on the comparative outcomes, clinical effectiveness, and appropriateness of pharmaceuticals, devices, and health care services to meet the needs of Medicare, Medicaid, and the Children’s Health Insurance Program (CHIP). AHRQ has an established network of Evidence-based Practice Centers (EPCs) that produce Evidence Reports/Technology Assessments to assist public- and...