Cba Ecuador Quito

SCIENTIFIC REPORT

Influence of Diazepam on Blood Glucose Levels
in Nondiabetic and Non-Insulin-dependent
Diabetic Subjects Under Dental Treatment With
Local Anesthesia
Vanessa Rocha LimaShcaira, DDS, MS,* Jose- Ranali, DDS, PhD,* Marrio Jose Abdalla Saad,
MD, PhD,t Patricia Cristine de Oliveira, DDS, MS,* Glaucia Maria Bovi Ambrosano, AgrEng,
PhD,t and Maria Cristina Volpato, DDS, PhD**Department of Physiological Sciences, Faculty of Dentistry of Piracicaba; tMedical Clinic, Faculty of Medical Science; tDepartment of
Social Dentistry, Faculty of Dentistry of Piracicaba, StateUniversity of Campinas, SP, Brazil

The effect of diazepam on blood glucose concentration (BGC) was investigated in
a double-blind cross-over study in 10 healthy and 10 non-insulin-dependent diabeticsubjects taking oral hypoglycemic drugs. In the first session, fasting blood samples
were taken for blood glucose and glycosylated hemoglobin estimation and at 60,
80, 95, 125, and 155 minutesthereafter for glucose estimation. In another 2 sessions, a venous sample was taken immediately before premedication (5 mg diazepam or placebo randomly given during breakfast). One hour later a bloodsample
was taken, and the volunteers were submitted to periodontal treatment after injection of 1.8 mL of 2% mepivacaine with 1: 100,000 adrenaline. Venous blood samples were taken at 15, 30, 60, and 90minutes after injection. The changes in BGC
were analyzed using analysis of variance (ANOVA) for repeated measures; the
means were compared using Tukey test (P = .05). Statistically significantdifferences
in the BGC were observed between diabetic and nondiabetic groups (P = .00003).
However, there were no significant differences among the sessions of the same
group (P = .29). The results ofthis study show that a single dose of 5 mg diazepam
before dental treatment does not influence BGC in nondiabetic and non-insulindependent diabetic subjects.
Key Words: Diazepam; Diabetes...