factores de coagulación

COAGULATION FACTORS AND THEIR PROBLEMS

Garcia. C. Christian Camilo1, Baron M. Iris Paola2, colina jeisson, gomez c. sebastian2.
UNIVERSITY OF APPLIED SCIENCE AND ENVIRONMENTAL U.D.C.A.
DEPARTMENT OF MEDICINE.
BOGOTÁ-COLOMBIA.


SUMMARY.

The human being as inclusive source aspects of emotional, intellectual and social, develops strategies necessary for the conservation of itsstructure and function, contributing each time to a better level and quality of life. The situation of disease can generate changes in the styles of life and psychosocial factors such as depression, hostility, anxiety, social isolation and stress, therefore develops the individual acquired a auto care to preserve the health, care and protect it. The circulatory system of the human being, is formed bythe heart and blood vessels and its fundamental task is to ensure the optimal circulation of the blood in various organs of the body; transports and distributes elements (nutrients, oxygen, hormones, among others) to each cell, and collects the waste produced by these. The endothelium intact keeps the blood in the liquid state by various mechanisms. Before an injury, hemostasis stops the bleeding intwo phases. Primary hemostasis controls the bleeding through vasoconstriction and platelet activation and is temporary. To the formation of fibrin is called secondary hemostasis. The hemostasis network requires a fibrin clot to fortify the platelet. The smooth phase converts fibrinogen to fibrin by thrombin. The formation of this depends on two tracks that differ in the way to activate theX-factor, because they share a common track after activation. The fibrinogen enabled polymerizes and form fibrils. In addition, the thrombin activates other factors; undergoes a slow autoactivation and active and adds platelets. The direct activation of the extrinsic pathway is brief and insufficient to sustain the hemostasis by what the intrinsic is indispensable for the hemostatic persistence. Thehemostasis and fibrinolysis are closely related forming and degraded fibrin. Fibrinolysis prevents the deposit of fibrin in the glass and prevents blockage of blood flow and depends on the enzyme plasmin which hydrolyses fibrinogen (fibrinogenolisis) and to the fibrin (fibrinolysis) producing products of degradation of fibrinogen or of the fibrin. The formation of the clot occurs and is maintainedonly where and when necessary. Your start-up, growth and maintenance are closely regulated, temporally and spatially. The plasma has agents that inhibit the activity of hemostatic and fibrinolytic factors that limit and locate the hemostasis and fibrinolysis.

Key words: Coagulopathies; hemostasis; Platelets; Fibronectin; hemophilias; Von Willebrand's disease.


INTRODUCTION.

Thecoagulopathies are very common diseases in the general population and affect people regardless of race, gender or social class, everything said so far, explains why you must have full knowledge of the pathogenesis, without leaving aside the full understanding and compression of the functioning of the clotting factors that are affected.

In the present work will be reflected results of hemostasis laboratorywhere, in addition were acquired new knowledge of diagnostic tests such as: partial thromboplastin time, prothrombin time, bleeding time, Count, and valuation of platelets, INR, and also identified the different reagents, materials and procedures for performing these laboratory tests that should allow the assessment and the extrinsic and intrinsic pathways of coagulation.

Below will beclarified and shall be construed the concerns, also will be explored in some significant pathologies of coagulation disorders, diseases such as the hemophilias and Von Willebrand disease.

GENERAL OBJECTIVES.

Based on the theoretical knowledge, distinguish the form in which they operate the various components of the coagulation and distinguish that any damage or malfunction in the expression of...