Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out—after graduating top of her class from medical school, she'll follow in her father's footsteps and become acardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this smallGulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable—the otherdoctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meetsZoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker – who just happens to be Lemon's fiance. Zoe is out of herelement and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself shehadn't known was there.
Rachel Bilson as Dr. Zoe Hart; Zoe aspires to be like her father and become a cardiothoracic surgeon. After four years of residency at a New York Hospital,Zoe does not get a fellowship and takes up an offer to move to the South and work in a small medical practice in the town of "Bluebell". There, she discovers her biological father had given her theposition; Hart decides to stay at the practice in order to learn from him.
Jaime King as Lemon Breeland, the daughter of town doctor Brick Breeland. She is currently engaged to George Tucker,however, after she appears to be jealous that Lavon brought Zoe to her engagement party, it is implied that she has had a relationship with him.
Cress Williams as Lavon Hayes, a linebacker for 10 years...
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