Updated information and services, including high-resolution figures, can be found in theonline version of this article at: http://www.sciencemag.org/cgi/content/full/295/5558/1311 Downloaded from www.sciencemag.org on June 27, 2009 Supporting Online Material can be found at: http://www.sciencemag.org/cgi/content/full/295/5558/1311/DC1 A list of selected additional articles on the Science Web sites related to this article can be found at:http://www.sciencemag.org/cgi/content/full/295/5558/1311#related-content This article cites 19 articles, 9 of which can be accessed for free: http://www.sciencemag.org/cgi/content/full/295/5558/1311#otherarticles This article has been cited by 65 article(s) on the ISI Web of Science. This article has been cited by 20 articles hosted by HighWire Press; see: http://www.sciencemag.org/cgi/content/full/295/5558/1311#otherarticles This articleappears in the following subject collections: Microbiology http://www.sciencemag.org/cgi/collection/microbio Information about obtaining reprints of this article or about obtaining permission to reproduce this article in whole or in part can be found at: http://www.sciencemag.org/about/permissions.dtl
Science (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last weekin December, by the American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. Copyright 2002 by the American Association for the Advancement of Science; all rights reserved. The title Science is a registered trademark of AAAS.
17. S. M. Burgess, N. Kleckner, Genes Dev. 13, 1871 (1999). 18. D. Zickler, N. Kleckner, Annu. Rev. Genet. 32, 619(1998). , Annu. Rev. Genet. 33, 603 (1999). 19. 20. R. Padmore, L. Cao, N. Kleckner, Cell 66, 1239 (1991). 21. N. Hunter, N. Kleckner, Cell 106, 59 (2001). 22. O. Kratky, G. Porod, Rec. Trav. Chim. 68, 1106 (1949). 23. P. J. Flory, Statistical Mechanism of Chain Molecules ( Wiley, New York, 1969). 24. K. Rippe, P. H. von Hippel, J. Langowski, Trends Biochem. Sci. 20, 500 (1995). 25. L. Ringrose, S.Chabanis, P. O. Angrand, C. Woodroofe, A. F. Stewart, EMBO J. 18, 6630 (1999). 26. K. Rippe, Trends Biochem. Sci. 26, 733 (2001). 27. P. Hahnfeldt, J. E. Hearst, D. J. Brenner, R. K. Sachs, L. R. Hlatky, Proc. Natl. Acad. Sci. U.S.A. 90, 7854 (1993). 28. S. E. Gerchman, V. Ramakrishnan, Proc. Natl. Acad. Sci. U.S.A. 84, 7802 (1987). 29. K. E. van Holde, Chromatin (Springer, Heidelberg, 1989). 30.The ﬂexibility of chromatin in higher eukaryotes is not ﬁrmly established. FISH analysis of mammalian chromosomes yielded values of l [l 137 to 440 nm (27) and l 196 to 272 nm (42)], whereas detailed in vitro experiments with single chromatin ﬁbers from chicken erythrocytes yielded lower values of l [l 60 nm (43)]. 31. The local concentration is maximal for sites separated by 1.7 times thestatistical segment length l . We estimate that the contour length of the yeast chromatin ﬁber is 11.1 nm/kb. A segment length of 56 to 69 nm (as determined in Fig. 3, A and B) will then correspond to 5.0 to 6.2 kb. The local concentration is therefore maximal for sites separated by 8.5 to 10.5 kb. 32. P. B. Moens, R. E. Pearlman, Bioessays 9, 151 (1988). 33. Y. Blat, N. Kleckner, Cell 98, 249 (1999). 34.S. Laloraya, V. Guacci, D. Koshland, J. Cell Biol. 151, 1047 (2000). 35. P. M. Sharp, A. T. Lloyd, Nucleic Acids Res. 21, 179 (1993). 36. B. Dujon, Trends Genet. 12, 263 (1996). 37. F. Baudat, A. Nicolas, Proc. Natl. Acad. Sci. U.S.A. 94, 5213 (1997). 38. J. L. Gerton et al., Proc. Natl. Acad. Sci. U.S.A. 97, 11383 (2000). 39. G. P. Holmquist, Am. J. Hum. Genet. 51, 17 (1992). 40. Given a table...