Asma

CONTEMPORARY HEMATOLOGY

MODERN HEMATOLOGY
Biology and Clinical Management SECOND EDITION
EDITED BY

Reinhold Munker, MD Erhard Hiller, MD Jonathan Glass, MD Ronald Paquette, MD

MODERN HEMATOLOGY
SECOND EDITION

CONTEMPORARY HEMATOLOGY
Gary J. Schiller, MD, SERIES EDITOR
Modern Hematology: Biology and Clinical Management, Second Edition, edited by REINHOLD MUNKER, ERHARD HILLER,JONATHAN GLASS, AND RONALD PAQUETTE, 2007 Stem Cell Transplantation for Hematologic Malignancies, edited by ROBERT J. SOIFFER, 2004 Biologic Therapy of Leukemia, edited by MATT KALAYCIO, 2003 Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management, by GUY B. FAGUET, 2003 Modern Hematology: Biology and Clinical Management, by REINHOLD MUNKER, ERHARD HILLER, AND RONALDPAQUETTE, 2000 Red Cell Transfusion: A Practical Guide, edited by MARION E. REID AND SANDRA J. NANCE, 1998

MODERN HEMATOLOGY
Biology and Clinical Management, Second Edition
Edited by

REINHOLD MUNKER, MD
Louisiana State University, Shreveport, LA

ERHARD HILLER, MD
Ludwigs-Maximilians Universität, Munich, Germany

JONATHAN GLASS, MD
Feist Weiller Cancer Center, Louisiana StateUniversity, Shreveport, LA

RONALD PAQUETTE, MD
University of California Los Angeles, Los Angeles, CA Foreword by

H. PHILLIP KOEFFLER, MD
Cedars-Sinai Medical Center, Los Angeles, CA

© 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 humanapress.com For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana atthe above address or at any of the following numbers: Tel: 973-256-1699; Fax: 973-256-8341; E-mail: orders@humanapr.com; website at humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from thePublisher. All articles, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. Due diligence has been taken by the publishers, editors, and authors of this book to ensure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure thatthe drug selections and dosages set forth in this text are accurate in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of eachdrug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible forerrors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication. This publication is printed on acid-free paper. ∞ ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. Production Editor: Tracy Catanese CoverIllustration: Figure 3 from Chapter 9, “Acute Myelogenous Leukemias” by Reinhold Munker. Cover design by Patricia F. Cleary. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $30.00 per copy is paid directly to the Copyright Clearance Center at 222 Rosewood Drive,...