Evc Cardioembólico

Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks (Review)
Aguilar MI, Hart R, Pearce LA

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2008, Issue 1 http://www.thecochranelibrary.comOral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks (Review) Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd

1

TABLE OF CONTENTS ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PLAIN LANGUAGE SUMMARY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CRITERIA FOR CONSIDERING STUDIES FOR THIS REVIEW . . . . . . . . . . . . . . . . . . SEARCH METHODS FOR IDENTIFICATION OF STUDIES . . . . . . . . . . . . . . . . . . .METHODS OF THE REVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DESCRIPTION OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . METHODOLOGICAL QUALITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . POTENTIAL CONFLICT OF INTEREST . . . . . . . . . . . . . . . . . . . . . . . . . . . SOURCES OF SUPPORT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . TABLES . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . Characteristics of included studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Characteristics of excluded studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ADDITIONAL TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Table 01. Study quality assessment . . . . . . . . . . . . . . . . . . . . . . . . .. . . . ANALYSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Comparison 01. Oral anticoagulant versus antiplatelet . . . . . . . . . . . . . . . . . . . . . . Comparison 02. Monotherapy antiplatelet trials . . . . . . . . . . . . . . . . . . . . . . . . INDEX TERMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . COVER SHEET . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . GRAPHS AND OTHER TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 01.01. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 01 All strokes (ischemic and hemorrhagic): primary outcome . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 01.02. Comparison 01 Oral anticoagulant versus antiplatelet,Outcome 02 Ischemic strokes (fatal and non-fatal) Analysis 01.03. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 03 All disabling or fatal strokes (ischemic and hemorrhagic) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 01.04. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 04 Myocardial infarction (fatal and non-fatal) . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . Analysis 01.05. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 05 Systemic (non-CNS) emboli . . Analysis 01.06. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 06 All intracranial hemorrhages . . Analysis 01.07. Comparison 01 Oral anticoagulant versus antiplatelet, Outcome 07 Major extracranial hemorrhage . Analysis 01.08....