Toxicologia

DOI:10.1158/1055-9965.EPI-04-0730

Residential Herbicide Use and Risk of Non-Hodgkin Lymphoma
Patricia Hartge, Joanne S. Colt, Richard K. Severson, et al. Cancer Epidemiol Biomarkers Prev 2005;14:934-937. Published online April 11, 2005.

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934 Cancer Epidemiology, Biomarkers & Prevention

Residential Herbicide Use and Risk of Non-Hodgkin Lymphoma
Patricia Hartge,1 Joanne S. Colt,1 Richard K. Severson,2 James R. Cerhan,3 Wendy Cozen,4 David Camann,5 Shelia Hoar Zahm,1 and Scott Davis6
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda,Maryland; 2Department of Family Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan; 3Mayo Clinic, College of Medicine, Rochester, Minnesota; 4University of Southern California, Los Angeles, California; 5Southwest Research Institute, San Antonio, Texas; and 6Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington
1

AbstractContext: Environmental exposure to herbicides has been hypothesized to contribute to the long-term increase in nonHodgkin lymphoma (NHL). Objective: To estimate the effects of residential herbicide exposure on NHL risk. Design: Population-based case-control study. Setting: Iowa and metropolitan Detroit, Los Angeles, and Seattle, 1998 to 2000. Participants: NHL patients ages 20 to 74 years and unaffectedresidents identified by random digit dialing and Medicare eligibility files. Main Outcome Measures: Computer-assisted personal interviews (1,321 cases, 1,057 controls) elicited data on herbicide use at each home occupied since 1970. Levels of 2,4dichlorophenoxy-acetic acid and dicamba were measured in dust taken from used vacuum cleaner bags in the current home (679 cases, 510 controls who hadowned at least half of their carpets for z5 years). Results: Herbicide use on the lawn or garden was similar among cases and controls (adjusted relative risk, 1.02; 95% confidence interval, 0.84-1.23). Estimated risk did not increase with greater duration, frequency, or total number of applications of herbicides to the lawn, the garden, or to both combined. Risk was not elevated for respondents whoapplied the herbicides themselves and not for those exposed during the 1970s, 1980s, or 1990s. We detected 2,4-dichlorophenoxy-acetic acid equally often in homes of cases and controls (78%). We found dicamba in homes of 15% of cases and 20% of controls. We also found no elevation in risk among the respondents who had the highest dust levels and highest self-reported exposures. We found noconsistent patterns for specific histologies. Conclusions: We found no detectable excess associated with residential exposures. Residential herbicide exposures are unlikely to explain the long-term increase in NHL. (Cancer Epidemiol Biomarkers Prev 2005;14(4):934 – 7)

Introduction
Non-Hodgkin lymphoma (NHL) comprises dozens of histologic entities (1-4), many with distinct etiologies. NHL incidence...