Ca Mama
Oncology
Oncology 2006;71:456–459
DOI: 10.1159/000107111
Received: September 21, 2006
Accepted after revision: April 28, 2007
Published online: August 9, 2007
Prognosis ofOccult Breast Carcinoma
Presenting as Isolated Axillary Nodal
Metastasis
Ramya Varadarajanb Stephen B. Edgea Jihnhee Yu a Nancy Watroba a
Bagi R. Janarthanan a
a
Departments of Medicine andSurgical Oncology, Roswell Park Cancer Institute, State University of New York at
Buffalo, Buffalo, N.Y., and b Department of Medicine, Rochester General Hospital, Rochester, N.Y., USA
Key WordsBreast cancer, occult Breast conservation
Abstract
A xillary metastasis from an occult breast carcinoma is an
uncommon presentation and presents a therapeutic dilemma. The objective of this studyis to describe the presenting
clinical features, management approach and treatment outcomes for occult breast carcinoma. We conducted a retrospective review of patients who presented with axillarynodal metastases from an occult breast carcinoma between
1997 and 2004 at the Roswell Park Cancer Institute; 2,150
patients were diagnosed and treated for breast cancer during this period. Afterexcluding stage I and IV patients, we
identified 642 who had disease metastatic to lymph nodes,
10 of these had no primary tumor in the breast despite a
thorough evaluation including bilateralmammography
and breast ultrasound. Of these, 7 had undergone breast
magnetic resonance imaging as well. All patients underwent axillary nodal dissection. The breast was managed
with radiotherapy alone in 8patients, wide local excision
with radiation therapy in 1 patient and 1 patient underwent
mastectomy. No patient had a recurrence with a median 57
months of follow-up. Breast conservation withradiation
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therapy alone can...
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