Anestesia

Score |
|
Unique Identifier | 19097962 |
Status | MEDLINE |
Authors | Huang CH. Wang YP. Wu PY. Chien CT. Cheng YJ. |
Authors Full Name | Huang, Chi-Hsiang. Wang, Yong-Ping. Wu, Pei-Yu.Chien, Chiang-Ting. Cheng, Ya-Jung. |
Institution | Department of Anesthesiology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan, ROC. |
Title | Propofol infusionshortens and attenuates oxidative stress during one lung ventilation. |
Source | Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists. 46(4):160-5, 2008 Dec. |Abstract | BACKGROUND: Resuming two lung ventilation (2LV) from one lung ventilation (OLV) has been proven to induce significant oxidative stress, mainly by superoxide release. Although totalintravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidant/antioxidant balance. METHODS: Thirty patients undergoing thoracic surgerywere randomly allocated to the propofol infusion (intravenous) group or isoflurane (inhalational) group after induction and placement of a double lumen endobronchial tube. Reactive oxygen species (ROS)production and total antioxidant status (TAS) were measured during OLV and 2LV manipulations. Blood samples were taken in the lateral position before OLV (T1), immediately before resuming 2LV (T2),and 5 minutes (T3) and 20 minutes (T4) after resuming 2LV, for measurement of ROS. RESULTS: ROS production increased significantly at T3 and T4 in both groups but to a lesser extent in the propofolinfusion group. TAS levels increased with time in the propofol group but not in the isoflurane group. CONCLUSION: Propofol infusion, compared with isoflurane inhalation, attenuates ROS production andlimits it for 20 minutes after resuming 2LV from OLV. Propofol infusion may be beneficial to patients with inadequate antioxidant capacity. |
Publication Type | Journal Article. Randomized Controlled...