Cancer
Páginas: 4 (999 palabras)
Publicado: 27 de enero de 2013
Jones et al. BMC Cancer 2010, 10:155 http://www.biomedcentral.com/1471-2407/10/155
STUDY PROTOCOL
Study protocol
Open Access
The lung cancer exercise training study: a randomized trial ofaerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design
Lee W Jones*1, Neil D Eves2, William E Kraus1, Anil Potti1, Jeffrey Crawford1, James ABlumenthal1, Bercedis L Peterson1 and Pamela S Douglas1
Abstract Background: The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types ofexercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that govern VO2peak in post-operative non-small cell lung cancer (NSCLC) patients.Methods/Design: Using a single-center, randomized design, 160 subjects (40 patients/study arm) with histologically confirmed stage I-IIIA NSCLC following curative-intent complete surgical resection at DukeUniversity Medical Center (DUMC) will be potentially eligible for this trial. Following baseline assessments, eligible participants will be randomly assigned to one of four conditions: (1) aerobictraining alone, (2) resistance training alone, (3) the combination of aerobic and resistance training, or (4) attention-control (progressive stretching). The ultimate goal for all exercise training groupswill be 3 supervised exercise sessions per week an intensity above 70% of the individually determined VO2peak for aerobic training and an intensity between 60 and 80% of one-repetition maximum forresistance training, for 30-45 minutes/session. Progressive stretching will be matched to the exercise groups in terms of program length (i.e., 16 weeks), social interaction (participants will receiveone-on-one instruction), and duration (30-45 mins/session). The primary study endpoint is VO2peak. Secondary endpoints include: patient-reported outcomes (PROs) (e.g., quality of life, fatigue,...
STUDY PROTOCOL
Study protocol
Open Access
The lung cancer exercise training study: a randomized trial ofaerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design
Lee W Jones*1, Neil D Eves2, William E Kraus1, Anil Potti1, Jeffrey Crawford1, James ABlumenthal1, Bercedis L Peterson1 and Pamela S Douglas1
Abstract Background: The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types ofexercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that govern VO2peak in post-operative non-small cell lung cancer (NSCLC) patients.Methods/Design: Using a single-center, randomized design, 160 subjects (40 patients/study arm) with histologically confirmed stage I-IIIA NSCLC following curative-intent complete surgical resection at DukeUniversity Medical Center (DUMC) will be potentially eligible for this trial. Following baseline assessments, eligible participants will be randomly assigned to one of four conditions: (1) aerobictraining alone, (2) resistance training alone, (3) the combination of aerobic and resistance training, or (4) attention-control (progressive stretching). The ultimate goal for all exercise training groupswill be 3 supervised exercise sessions per week an intensity above 70% of the individually determined VO2peak for aerobic training and an intensity between 60 and 80% of one-repetition maximum forresistance training, for 30-45 minutes/session. Progressive stretching will be matched to the exercise groups in terms of program length (i.e., 16 weeks), social interaction (participants will receiveone-on-one instruction), and duration (30-45 mins/session). The primary study endpoint is VO2peak. Secondary endpoints include: patient-reported outcomes (PROs) (e.g., quality of life, fatigue,...
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