Blackwell Publishing Ltd
Dental pulp stem cells: what, where, how?
Dental pulp stem cells
ALASTAIR J. SLOAN & RACHEL J. WADDINGTONMineralised Tissue Research Group, Tissue Engineering and Regenerative Dentistry, School of Dentistry Cardiff University, UK
International Journal of Paediatric Dentistry 2009; 19: 61–70
Introduction. Itis now accepted that progenitor/ stem cells reside within the post-natal dental pulp. Studies have identiﬁed several niches of multipotent mesenchymal progenitor cells, known as dental pulp stemcells, which have a high proliferative potential for self-renewal. These progenitor stem cells are now recognized as being vital to the dentine regeneration process following injury. Understanding thenature of these progenitor/stem cell populations in the pulp is important in determining their potentialities and development of isolation or recruitment strategies for use in regeneration and
tissueengineering. Characterization of these cells, and determination of their potentialities in terms of speciﬁcity of regenerative response, may help direct new clinical treatment modalities. Such noveltreatments may involve controlled direct recruitment of the cells in situ and possible seeding of stem cells at sites of injury for regeneration or use of the stem cells with appropriate scaffolds fortissue engineering solutions. Such approaches may provide an innovative and novel biologically based new generation of clinical materials and/or treatments for dental disease. Aim. This study aimed toreview the body of knowledge relating to stem cells and to consider the possibility of these cell populations, and related technology, in future clinical applications.
Thedentine–pulp complex has a natural regenerative potential leading to the formation of tertiary dentine. Odontoblasts may survive mild injury, such as attrition or early caries, and secrete a reactionary...