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Invest Clin 50(4): 447 - 454, 2009

Human papillomavirus false positive cytological diagnosis in low grade squamous intraepithelial lesion.
José Núñez-Troconis1, Mariela Delgado2, JuliaGonzález2, Jesvy Velásquez3, Raimy Mindiola3, Denise Whitby4, Betty Conde4 and David J. Munroe5. Hospital Manuel Noriega Trigo, Departamento de Obstetricia y Ginecología, Facultad deMedicina, Universidad del Zulia, Maracaibo, Venezuela; 2Laboratorio de Patología, Policlínica Maracaibo; Maracaibo, Venezuela, 3Laboratorio Regional de Referencia Virológica, Facultad de Medicina,Universidad del Zulia, Maracaibo, Venezuela; 4Viral Oncology Section (VOS) Core Laboratory, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA; 5Laboratory ofMolecular Technology. SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA.
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Key words: Human Papillomavirus, false positive, low-grade squamousintraepithelial lesion, pap smear, hybrid capture 2. Abstract. The purpose of this study was to investigate the number of Human Papillomavirus false positive cytological diagnosis in low grade squamousintraepithelial lesions (LSIL). Three hundred and two women who assisted to an Out-Patient Gynecologic Clinic in Maracaibo, Venezuela, were recruited for this study. Each patient had the Papsmear and a cervical swab for Hybrid Capture 2 (HC2). Three cytotechnologists reviewed the Pap smears and two pathologists rescreened all of them. The cytotechnologists reported 161 (53.3%)Pap smears negatives for intraepithelial lesion (IL) or malignancy, and 141 cases (46.7%) with epithelial abnormalities. They reported 46% of 302 patients with HPV infection in Pap smearslides. The pathologists found that 241 (79.8%) Pap smears were negatives for IL or malignancy and 61 (20.2%), with abnormal Pap smears. They found 14.6% HPV infection in all Pap smears (p
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