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  • Publicado : 15 de marzo de 2012
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Introduction

This formal investigation is about effect of aspartame in the development and growth of mus musculus, aspartame is a non-caloric sweetener discovered in 1965 and marketed in the eighties. Numerous national and international organizations have assessed the safety of aspartame and an international committee of experts has established a level of intake (ADI). Aspartame is made ​​fromtwo amino acids or protein components: aspartic acid and phenylalanine.

       Aspartic acid and phenylalanine are building blocks of protein found in all protein foods, including meats, grains and dairy products. Aspartame is formed when these two amino acids together, and adds a methyl group. This methyl group is unfolded during digestion and is methanol. Methanol is found naturally in thebody and in many foods such as fruit and vegetable juices. The body metabolizes the amino acids in aspartame the same way it does with those obtained from other protein foods.

       What we do in this project is to give drink to four mice with aspartame that is going to be diluted with water to give the first 5 grams to 7 grams give second, third and fourth 10 grams 12 grams. Control mice have3 to compare the results. To test the possible damage that may be causing them, the will to walk a labyrinth from time to time.

      After that we will publish the results to raise public awareness to stop using products with it. Because as has been believed that aspartame is a possible cause of brain tumors in humans, and also cause cancer in this same body and not suffer from these diseases.Objective

* Check that aspartame causes problems in the nervous system of humans.
* Know what is the maximum amount of aspartame that humans could consume to avoid problems.
* Post your results to raise public awareness to stop using products with this substance

Justification

The reason we do this project is to draw conclusions about whether, indeed, aspartame causessevere health damage as this is a substance found in many food products today.


Data collection

Mus musculus
The laboratory mouse is a rodent, usually of the species Mus musculus, which is used for scientific research. Its karyotype is composed of 40 cromosomas1 and are usually albinos.
For each experiment mice were chosen belonging to the same pure strain or inbred. Individuals of the samestrain carrying the same genes, thus facilitating the comparison of the effects of different experimental treatments, without causing confusion due to genetic differences.

The most commonly used strain is the BALB / c, but there are others available, especially since the development of gene manipulation techniques have provided a large number of strains with specific genetic modifications Thecharacteristics that have made ​​the laboratory mouse biological and biomedical model most commonly used in scientific research are:

1. Easy handling.
2. Appropriate size for the breeding and handling.
3. Not require much care.
4. Have an immune system similar to humans.
5. Have a high number of offspring.
6. They have a short gestation period (19-21 days), and his weaning is rapid.
7.Females produce large numbers of eggs, which when fertilized are very resilient.
8. When eutherian mammals, have a genome very similar to humans.

Mice have a genome grouped into 20 pairs of chromosomes, while humans have 23. The genomes of humans and mice are very similar; the human genome has 2,900 million base pairs, while the mouse contains approximately 2,600 million

AspartameAspartame is a non-caloric sweetener discovered in 1965 and marketed in the eighties. Numerous national and international organizations have assessed the safety of aspartame and an international committee of experts has established a level of intake (ADI). However, some voices have reopened the debate about the risks that aspartame could pose to health.
Aspartame is a white, odorless powder that is...
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