Referencias bibliograficas

Br. Liliana Peñaloza
Referencias bibliograficas que tienen relación con el efecto farmacologico de Pleurotus ostreatus. Secuencias proteínicas de aminoacidos de Laccase – Basidiomicetes en archivo fasta con sus caracteristicas respectivas.

1. Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
ANDREJJEDINAK1 and DANIEL SLIVA1,2,3
1 Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN, USA
2 Department of Medicine, Indiana University, Indianapolis, IN, USA
3 IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN, USA
Correspondence to: Dr D. Sliva, Cancer Research Laboratory, Methodist Research Institute, 1800 N. Capitol Ave, E504,Indianapolis, IN 46202, USA, Email: dsliva@clarian.org
The publisher's final edited version of this article is available at Int J Oncol

Abstract
In spite of the global consumption of mushrooms, only two epidemiological studies demonstrated an inverse correlation between mushroom intake and the risk of cancer. Therefore, in the present study we evaluated whether extracts from edible mushrooms Agaricusbisporus (portabella), Flammulina velutipes (enoki), Lentinula edodes (shiitake) and Pleurotus ostreatus (oyster) affect the growth of breast and colon cancer cells. Here, we identified as the most potent, P. ostreatus (oyster mushroom) which suppressed proliferation of breast cancer (MCF-7, MDA-MB-231) and colon cancer (HT-29, HCT-116) cells, without affecting proliferation of epithelial mammaryMCF-10A and normal colon FHC cells. Flow cytometry revealed that the inhibition of cell proliferation by P. ostreatus was associated with the cell cycle arrest at G0/G1 phase in MCF-7 and HT-29 cells. Moreover, P. ostreatus induced the expression of the tumor suppressor p53 and cyclin-dependent kinase inhibitor p21(CIP1/WAF1), whereas inhibited the phosphorylation of retinoblastoma Rb protein inMCF-7 cells. In addition, P. ostreatus also up-regulated expression of p21 and inhibited Rb phosphorylation in HT-29 cells, suggesting that that P. ostreatus suppresses the proliferation of breast and colon cancer cells via p53-dependent as well as p53-independent pathway. In conclusion, our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast andcolon cancer.
Keywords: mushroom, breast cancer, prostate cancer, cell proliferation.

2. Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment
Keith R Martin1
1Healthy Lifestyles Research Center, College of Nursing and Health Innovation, Arizona State University, 6950East Williams Field Road, Mesa, AZ 85212, USA
Corresponding author.
Keith R Martin: Keith.R.Martin@asu.edu
Received May 12, 2010; Accepted July 16, 2010.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided theoriginal work is properly cited.
Abstract
Background
Cardiovascular disease (CVD) is a leading cause of mortality in the United States as well as globally. Epidemiological studies show that regular fruit and vegetable consumption reduces CVD risk, in part, due to antioxidant activity and immunomodulation since oxidative stress and inflammation are features of atherogenesis. Accumulating evidencealso shows that dietary fungi, viz., mushrooms, can protect against chronic disease by altering inflammatory environments such as those associated with CVD although most research has focused on specialty mushrooms. In this study, we tested the ability of both common and specialty mushrooms to inhibit cellular processes associated with CVD.

J Hematol Oncol. 2009; 2: 25. Publicado en Internet...