0031-6997/03/5504-597–606$7.00 PHARMACOLOGICAL REVIEWS Copyright © 2003 by The American Society for Pharmacology and Experimental Therapeutics Pharmacol Rev 55:597–606, 2003

Vol. 55, No. 430404/1114803 Printed in U.S.A

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology
RICHARD R.NEUBIG, MICHAEL SPEDDING, TERRY KENAKIN, AND ARTHUR CHRISTOPOULOS Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (R.R.N.); Institute de Recherches Internationales Servier,Neuilly sur Seine, France (M.S.); Systems Research, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina (T.K.); and Department of Pharmacology, University of Melbourne,Parkville, Australia (A.C.)

Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I.Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . II. Working definition of a receptor .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . III. Use of drugs in definition of receptors or of signaling pathways . . . . . . . .. . . . . . . . . . . . . . . . . . . . . A. The expression of amount of drug: concentration and dose . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. Concentration.. . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Dose. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. General terms used to describe drug action . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... [continua]

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