Univeristario

Personalized Medicine
Real life experiences

André Neu
Director European Imaging

Healthcare is Personal
99.9% of human DNA identical among unrelated individuals Physicians feel they are already practicing “Personalized Medicine“ Genetics just one piece to personalization of medicine
Combine multiple dimensions into decisions
• Biology • Environment
    Social Economic FamilyBehavior

• Genomics

Magnify focus on person

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Factors Influencing Outcomes

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Personalized Medicine in Practice
“The right treatment for the right person at the right time” The ideal treatment effectively treats or prevents disease and has no adverse effects The use of genetic and other laboratory test results, along with clinical information, in makingtreatment decisions for a particular individual Optimization of drug therapy with respect to patient„s genotype – maximum efficacy with minimum adverse effects Consideration of other influencing personal factors

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From Research to Clinical Adoption
Difficult

Research
Cost

Data
Cost

Clinical Studies

Random

Clinical Practice
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FromResearch to Clinical Adoption
Difficult

Research
Cost

Data Knowledge
Random Cost

Clinical Studies

Clinical Practice
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Information Overload
How is physician / knowledgeworker time spent?

35%

Seeing patients Looking for information

65%

IDC report. S. Feldman "The high cost of not finding information“ KM World

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Reasons…

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Requirements
Patient-centric EMR Discrete data
Scanning of reports is insufficient Without interface to outside labs, re-entry of data may become necessary Enormous amounts of data storedfor possible future analysis

Leveraging value in data across patient populations
From one to many to one Closing the loop

Increase pace of knowledge adoption Costs for diagnostic and prognostic tests Making knowledge available and easy to locate
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Genetics and other Use Cases

Genotyping Examples
Breast cancer
Her2/Neu-protein over-expression in breast cancer due to genetic mutation If tumor tissue tests positive for this protein, Herceptin is prescribed Herceptin specifically targets the HER2 protein

Chronic myelogenous leukemia (CML)
95% of people have a...