Vaginosis

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Ann Intern Med. Author manuscript; available in PMC 2009 January 26.
Published in final edited form as: Ann Intern Med. 2008 July 1; 149(1): 20–28.

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Relationship of Specific Vaginal Bacteria and Bacterial Vaginosis Treatment Failure in Women Who Have Sex with Women: A CohortStudy
Jeanne M. Marrazzo, MD, MPH1, Katherine K. Thomas, MS1, Tina L. Fiedler, BS2, Kathleen Ringwood, MSW1, and David N. Fredricks, MD1,2 1Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 2Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA

Abstract
Background—Bacterial vaginosis frequently persists aftertreatment. The role of newly defined bacterial vaginosis-associated bacteria (BVAB), with specificity ≥97% for this condition, has not been assessed. Objective—Define risks for bacterial vaginosis persistence, including pre-treatment detection of specific vaginal bacteria, among women reporting sex with other women. Design—Observational cohort study. Setting—University-based research clinic.Patients—335 women 16–29 years-old reporting sex with ≥1 woman in the prior year recruited through advertisements and provider referral.

Corresponding Author: Jeanne M. Marrazzo, MD, MPH, Harborview Medical Center, Division of Infectious Diseases, 325 Ninth Avenue, Mailbox #359931, Seattle, WA 98104, Phone: 206-744-3679, Fax: 206-744-3693, Email: jmm2@u.washington.edu. Address requests for reprintsto Dr. Jeanne Marrazzo, Harborview Medical Center, Mailbox #359931, 325 Ninth Avenue, Seattle, WA 98104; phone (206) 731-3679; fax (206) 731-3693; email jmm2@u.washington.edu Current Author Addresses: Jeanne Marrazzo, MD, MPH, Harborview Medical Center, Division of Infectious Diseases, 325 Ninth Avenue, Mailbox #359931, Seattle, WA 98104, Phone: 206-744-3679, Fax: 206-744-3693, Email:jmm2@u.washington.edu Katherine K. Thomas, MS, Harborview Medical Center, Division of Infectious Diseases, 325 Ninth Avenue, Mailbox #359931, Seattle, WA 98104, Phone: 206-744-2127, Fax: 206-744-3693, Email: kkthomas@u.washington.edu Tina Fiedler, BS, Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Box 19024, Seattle, WA 98109-1024, Phone: 206-667-1935,Fax: 206-667-4411, Email: tfiedler@fhcrc.org Kathleen Ringwood, MSW, Harborview Women's Research Clinic, 600 Broadway, Suite 385, Seattle, WA 98104, Phone: 206-720-5063, Fax: 206-720-5051 David N. Fredricks, MD, Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Box 19024, Seattle, WA 98109-1024, Phone: 206-667-1935, Fax: 206-667-4411, Email:dfredric@fhcrc.org This is the pre-publication, author-produced version of a manuscript accepted for publication in Annals of Internal Medicine. This version does not include post-acceptance editing and formatting. The American College of Physicians, the publisher of Annals of Internal Medicine, is not responsible for the content or presentation of the author-produced accepted version of the manuscriptor any version that a third party derives from it. Readers who wish to access the definitive published version of this manuscript and any ancillary material related to this manuscript (correspondence, corrections, editorials, linked articles, etc…) should go to www.annals.org or to the print issue in which the article appears. Those who cite this manuscript should cite the published version, asit is the official version of record. Reproducible Research Statements Protocol: available to interested readers by contacting Dr. Marrazzo at jmm2@u.washington.edu Statistical Code: available to interested readers by contacting Ms. Thomas at kkt@u.washington.edu Data: not available

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Intervention—Bacterial vaginosis was treated with intravaginal metronidazole gel...