Chromosomes, genes, alleles and mutations
Centro Escolar Campoalegre María Gabriela Macz
CHROMOSOMES, GENES, ALLELES AND MUTATIONS
When living things reproduce, they pass on characteristics to their offspring(the offspring inherit the parent’s characteristics) Some characteristics may not be inherited Inheritance has been discussed since the time of Hippocrates and earlier Aristotleobserved that children sometimes resembled their grandparents more than their parents Many of these theories involved blending inheritance, in which offspring inherit characteristics from both parents (intermediate characteristics) Prokaryotes chromosomes are circular
PROKARYOTIC DNA
PROKARYOTIC DNA IN THE NUCLEOID REGION
Prokaryotes have some DNA in the form of small loops calledPLASMIDS Prokaryote DNA is found in the nucleoid area of the cell not in the nucleus Prokaryotic chromosomes contain DNA but not proteins Eukaryotic chromosomes are found inside the nucleus ( http://www.dnalc.org/resources/3d/07-how-dna-ispackaged-basic.htm or http://www.dnalc.org/resources/3d/08-how-dna-is-packaged-advanced.html ) There are usually more than one chromosome and they arelinear Eukaryotic chromosomes contain DNA and protein (read Document 4.2 Meiosis)
Biology, 2011
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Chromosomes, genes, alleles and mutations
Centro Escolar Campoalegre María Gabriela Macz
THE PACKING OF CHROMATIN
EUKARYOTIC CROMOSOME
Genetics is the study of variations and inheritance
Biology, 2011
2
Chromosomes, genes, alleles and mutations
Centro EscolarCampoalegre María Gabriela Macz
The basic unit of inheritance is the GENE GENE: is an inheritable factor that controls a specific characteristic Factor that controls a specific characteristic Consists of a length of DNA Atypical animal or plant chromosome contains about a 1000 genes Arranged in linear sequence In any particular type of chromosome the same genes are found arranged in thesame sequence A total number of genes in a human chromosome is about 25000 Occupies a position on a chromosome known as locus LOCUS: the particular position on homologous chromosomes of a gene The term allele refers to one specific form of a gene, differing from other alleles by one or a few bases only and occupying the same gene locus as other alleles of a gene Different forms of manygenes can be found ALLELE: one of a number of different forms of a gene They differ by a few bases at the most A genome is the total genetic material of an organelle, cell or organism The whole of the genetic inform ation of an organisms Entire haploid complement of a genetic material Every cell in an individual has a complete copy of the genome Each specie has a unique genome There isa small variation between individuals of the same species In humans the average of genetic variation in one in every 500-1000 bases Genes are almost passed from parents to offspring without being changes, occasionally genes do change MUTATION: permanent change in the sequence of base pair in the DNA that makes up a gene (change to the base sequence of a gene) Mutations originate newvariations They create new alleles and form an important part of the evolutionary process Most mutations are harmful, but there is a significant mutations that SILENT and do not appear to have any effect on the individual There could be gene mutations or chromosome mutations
Biology, 2011
3
Chromosomes, genes, alleles and mutations
Centro Escolar Campoalegre María Gabriela Macz
1.GENE MUT ATION: Mutations may cause alteration in the genetic instructions coded in the DNA of chromosomes Most mutations are harmful some are neutral while some provide some improveme nt on the earlier version of the gene Mutations may be accumulated (inherited) over many generations 2. CHROMOSOME MUTATION: Pieces of chromosomes may be rearrange during meiosis Pieces may be turned...
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