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ENZYME: 3.2.1.108 | |

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Principio del formulario Entry | EC 3.2.1.108                Enzyme                                  | |
|
Name |lactase;
lactase-phlorizin hydrolase |
Class | Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
|
Sysname | lactose galactohydrolase |Reaction(IUBMB) | lactose + H2O = D-galactose + D-glucose [RN:R01100 R06114] |
Reaction(KEGG) | R01100 R06114(G) > R01678 R06098(G)
|
Substrate | lactose [CPD:C00243];
H2O [CPD:C00001] |
Product| D-galactose [CPD:C00124];
D-glucose [CPD:C00031] |
Comment | The enzyme from intestinal mucosa is isolated as a complex that also
catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf.EC
3.2.1.33 amylo-alpha-1,6-glucosidase. |
Pathway | ec00052  Galactose metabolism
ec01100  Metabolic pathways |
Orthology | K01229  lactase-phlorizin hydrolase |
Genes | HSA: 3938(LCT)
MCC:707761(LCT)
MMU: 226413(Lct)
RNO: 116569(Lct)
CFA: 483898(LCT)
BTA: 514332(LCT)
ECB: 100055369
OAA: 100084941
GGA: 424294(LCT)
TGU: 100229941
XLA: 100127248(lct)
DRE: 796436
BFO:BRAFLDRAFT_105101(SUFU)
CIN: 100186561
|
Reference
  Authors
  Title

  Journal
  Organism
| 1  [PMID:5082068]
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G.
A second enzyme defect in acquiredlactase deficiency: lack of
small-intestinal phlorizin-hydrolase.
Eur. J. Clin. Invest. 2 (1972) 326-31.
Homo sapiens [GN:hsa] |
Reference
  Authors
  Title

  Journal
  Organism
|2  [PMID:810166]
Ramaswamy S, Radhakrishnan AN.
Lactase-phlorizin hydrolase complex from monkey small intestine.
Purification, properties and evidence for two catalytic sites.
Biochim. Biophys. Acta. 403(1975) 446-55.
monkey |
Reference
  Authors
  Title
  Journal
  Organism
| 3  [PMID:5010299]
Schlegel-Haueter S, Hore P, Kerry KR, Semenza G.
The preparation of lactase and glucoamylase...
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