Plasticidad cerebral

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene Avshalom Caspi, et al. Science 301, 386 (2003); DOI: 10.1126/science.1083968
This copy is for your personal, non-commercial use only.

If you wish to distribute this article to others, you can order high-quality copies for your colleagues, clients, or customers by clicking here. Permission to republish orrepurpose articles or portions of articles can be obtained by following the guidelines here. The following resources related to this article are available online at www.sciencemag.org (this information is current as of March 26, 2010 ): Updated information and services, including high-resolution figures, can be found in the online version of this article at:http://www.sciencemag.org/cgi/content/full/301/5631/386 Supporting Online Material can be found at: http://www.sciencemag.org/cgi/content/full/301/5631/386/DC1 A list of selected additional articles on the Science Web sites related to this article can be found at: http://www.sciencemag.org/cgi/content/full/301/5631/386#related-content This article cites 22 articles, 11 of which can be accessed for free:http://www.sciencemag.org/cgi/content/full/301/5631/386#otherarticles This article has been cited by 1776 article(s) on the ISI Web of Science. This article has been cited by 89 articles hosted by HighWire Press; see: http://www.sciencemag.org/cgi/content/full/301/5631/386#otherarticles This article appears in the following subject collections: Psychology http://www.sciencemag.org/cgi/collection/psychology

Science (print ISSN0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. Copyright 2003 by the American Association for the Advancement of Science; all rights reserved. The title Science is a registered trademark of AAAS.

Downloaded from www.sciencemag.org on March 26, 2010REPORTS
Fig. 4. PPI of the right ACC. (A) All areas are shown that receive a significant context-dependent contribution from right ACC during visuospatial decisions, projected on the same rendered brain as in Fig. 1. Right ACC significantly increased its influence on posterior (28/–72/48, t max 4.49, P 0.015, corrected) and anterior parts of the right IPS (42/–42/44, t max 4.63, P 0.034,corrected) during visuospatial decisions. Note the specificity of this result: Even when the threshold was reduced to P 0.05, uncorrected, no other significant clusters were found throughout the brain. (B) This schema summarizes the negative findings for right ACC: As indicated by the gray dashed lines, right ACC shows no context-dependent contributions to any left-hemispheric area during visuospatialdecisions and none to any left- or right-hemispheric area at all during letter decisions.
22. G. R. Fink et al., Brain 122, 497 (1999). 23. C. Buchel, K. J. Friston, Cereb. Cortex 7, 768 (1997). ¨ 24. A. K. Engel, P. Fries, W. Singer, Nature Rev. Neurosci. 2, 704 (2001). 25. A. R. McIntosh et al., J. Neurosci. 14, 655 (1994). 26. G. Bush, P. Luu, M. I. Posner, Trends Cogn. Sci. 4, 215 (2000). 27. K.J. Friston et al., NeuroImage 6, 218 (1997). 28. C. Cavada, P. S. Goldman-Rakic, J. Comp. Neurol. 287, 393 (1989). 29. D. N. Pandya, G. W. Van Hoesen, M. M. Mesulam, Exp. Brain Res. 42, 319 (1981). 30. This work was supported by the Deutsche Forschungsgemeinschaft (K.Z., G.R.F), the U.K. Medical Research Council ( J.C.M), and the Wellcome Trust (K.E.S., K.J.F). Additional support for this HumanBrain Project/Neuroinformatics research was provided jointly by the National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Drug Abuse, and the National Cancer Institute. We thank our volunteers, K. Amunts for helpful anatomical discussions, and the radiographers at the Research Center Julich for tech¨ nical assistance. Supporting Online...