Pruebas funcion renal

SENSIBILIDAD Y ESPECIFICIDAD DE PRUEBAS DE FUNCIÓN RENAL

BETA 2 MICROGLOBULINA (B2MG):

SENSIBILIDAD: 93%
ESPECIFICIDAD: 100%

CITURIA CUANTITATIVA EN ORINA:

SENSIBILIDAD: 84.5%ESPECIFICIDAD: 99.7%


PARCIAL DE ORINA:

SENSIBILIDAD: 65.6%
ESPECIFICIDAD: 99.2%

CLEARANCE DE CREATININA CALCULADO:

SENSIBILIDAD: 80%
ESPECIFICIDAD: 81.1%


COCKCROFT- GAULT:SENSIBILIDAD: 90.6
ESPECIFICIDAD: 79

FRACCIÓN EXCRETADA DE SODIO:

SENSIBILIDAD: 90%
ESPECIFICIDAD: 90%

MDRD-4

SENSIBILIDAD: 97%
ESPECIFICIDAD: 67%

MDRD-6

SENSIBILIDAD: 97%ESPECIFICIDAD: 70%

NUEVOS BIOMARCADORES DE DAÑO RENAL AGUDO

Biomarker | Type | Description |
Albumin | Filtered- a. Glomerular b. Impaired tubular absorption | Normal serum constituent |
Aprotinin| Filtered | Exogenous |
Cystatin C | Filtered- Impaired tubular absorption | Normal serum constituent |
β2-microglobulin | Filtered- Impaired tubular absorption | Normal serum constituent |Liver Fatty Acid Binding Protein (L-FABP; FABP1) | Pre-formed and Filtered-Impaired tubular absorption | Proximal convoluted tubule cytoplasm |
Alkaline Phosphatase (ALP) | Pre-formed | Proximaltubule brush border |
γ-glutamyl transpeptidase (GGT) | Pre-formed | Proximal tubule brush border |
α-glutathione S transferase (α-GST) | Pre-formed | Proximal tubule cells |
π-glutathione Stransferase (π-GST) | Pre-formed | Distal tubule cells |
N-acetyl-beta-D-glucosaminidase (NAG) | Pre-formed | Proximal tubule lysosomes |
Clusterin | Up-regulated | Proximal tubules in outer medulla(pre-formed in distal tubule) |
Interleukin 18 (IL-18) | Up-regulated in proximal epithelial cells and recruited macrophages | Pro-inflammatory cytokine |
Kidney Injury Molecule 1 (KIM-1) |Up-regulated | Proximal tubule cells |
Netrin-1 | Up-regulated | Tubular epithelial cells |
Neutrophil Gelatinase Associated Lipocalin (NGAL) | Up-regulated | Distal tubule cells (absorbed in proximal...