Historia Clinica Traumatologica

Antibiotics for treating chronic osteomyelitis in adults (Review)
Conterno LO, da Silva Filho CR

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2009, Issue 3 http://www.thecochranelibrary.com

Antibiotics for treating chronic osteomyelitis in adults (Review) Copyright © 2009 The Cochrane Collaboration.Published by John Wiley & Sons, Ltd.

TABLE OF CONTENTS HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DATA AND ANALYSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 1.1. Comparison 1 Oral antibiotic versusparenteral antibiotic (AB), Outcome 1 Remission at the end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 1.2. Comparison 1 Oral antibiotic versus parenteral antibiotic (AB), Outcome 2 Remission at least 12 months after the end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 1.3. Comparison 1 Oral antibiotic versusparenteral antibiotic (AB), Outcome 3 Mild adverse events. . . . Analysis 1.4. Comparison 1 Oral antibiotic versus parenteral antibiotic (AB), Outcome 4 Moderate or severe adverse events. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 1.5. Comparison 1 Oral antibiotic versus parenteral antibiotic (AB), Outcome 5 Superinfection. . . . . Analysis 2.1. Comparison 2Parenteral plus oral antibiotics versus parenteral antibiotic, Outcome 1 Remission at least 12 months after the end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 2.2. Comparison 2 Parenteral plus oral antibiotics versus parenteral antibiotic, Outcome 2 Adverse events. . Analysis 3.1. Comparison 3 Oral antibiotic 1 versus oral antibiotic 2, Outcome 1 Remission at least 12months after the end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 3.2. Comparison 3 Oral antibiotic 1 versus oral antibiotic 2, Outcome 2 Adverse events. . . . . . . . Analysis 4.1. Comparison 4 Parenteral antibiotic 1 versus parenteral antibiotic 2, Outcome 1 Remission at least 12 months after the end of the treatment. . . . . . . . . . . . . . . . . . . .. . . . . . . . . Analysis 4.2. Comparison 4 Parenteral antibiotic 1 versus parenteral antibiotic 2, Outcome 2 Adverse events. . . . Analysis 4.3. Comparison 4 Parenteral antibiotic 1 versus parenteral antibiotic 2, Outcome 3 Superinfection. . . . ADDITIONAL TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . APPENDICES . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CONTRIBUTIONS OF AUTHORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DECLARATIONS OF INTEREST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SOURCES OF SUPPORT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DIFFERENCES BETWEEN PROTOCOL AND REVIEW...