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toxicologist’s POCKET HANDBOOK
Michael J. Derelanko, Ph.D., D.A.B.T., F.A.T.S.
Department of Toxicology and Risk Assessment Honeywell International Inc. Morristown, New Jersey

CRC Press Boca Raton London New York Washington, D.C.

© 2000 by CRC Press LLC

Library of Congress Cataloging-in-Publication Data Cataloging information is available from the Library of Congress.

This bookcontains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use.Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or forresale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC, 2000 N.W. Corporate Blvd., Boca Raton, Florida 33431. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe. © 2000 by CRC Press LLC No claim to originalU.S. Government works International Standard Book Number 0-8493-0009-6 Printed in the United States of America 1 2 3 4 5 6 7 8 9 0 Printed on acid-free paper

© 2000 by CRC Press LLC

ABOUT

THE

AUTHOR

Michael J. Derelanko, Ph.D., D.A.B.T., F.A.T.S., is Manager of Toxicology and Risk Assessment at Honeywell International Inc. (formerly AlliedSignal Inc.), Morristown, New Jersey. Hereceived his B.S. degree from Saint Peter’s College in 1973. He was a National Institute of Health predoctoral trainee in the Albert S. Gordon Laboratory of Experimental Hematology at New York University, receiving M.S. and Ph.D. degrees. He received the 1976 New York University Gladys Mateyko Award for Excellence in Biology. Following a two-year postdoctoral fellowship in pharmacology atSchering-Plough Corporation, he began his career in industrial toxicology in 1980 in the corporate toxicology laboratories of, what was at that time, Allied Chemical. Dr. Derelanko is a Diplomate of the American Board of Toxicology and a Fellow of the Academy of Toxicological Sciences. He is a member of the Society of Toxicology, the Society for Experimental Biology and Medicine, and the honorary researchsociety, Sigma Xi. He has served on the content advisory committee of the New Jersey Liberty Science Center, has chaired or been a member of industrial and government toxicology advisory committees, and serves on the speaker’s bureau of the New Jersey Association for Biomedical Research. Dr. Derelanko has authored more than 50 publications in experimental hematology, gastrointestinal pharmacology,and toxicology. He is co-editor along with Dr. Manfred Hollinger of the CRC Handbook of Toxicology. He has been actively involved in educating the public about toxicology, particularly at the middle school level, and has delivered invited lectures on this subject at national meetings. His current research interests include understanding the toxicity of aliphatic oximes.

© 2000 by CRC Press LLC DEDICATION
To all toxicologists in recognition of their efforts to protect human health and the environment.

© 2000 by CRC Press LLC

PREFACE
Toxicologists rely on a large information base to design, conduct, and interpret toxicology studies and to perform risk assessments. Reference books such as the CRC Handbook of Toxicology kept in the toxicologist’s office supply ready access to...
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