Regeneracion hepatica

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Anna Mae Diehl
Am J Physiol Gastrointest Liver Physiol 288:1-6, 2005. doi:10.1152/ajpgi.00376.2004 You might find this additional information useful... This article cites 25 articles, 11 of which you can access free at: This article has been cited by 2 other HighWire hosted articles: Early features of acute-on-chronic alcoholic liverfailure: a prospective cohort study A. Katoonizadeh, W. Laleman, C. Verslype, A. Wilmer, G. Maleux, T. Roskams and F. Nevens Gut, July 30, 2010; 0 (2010): gut.2009.189639v1-gut.2009.189639. [Abstract] [Full Text] Calmodulin Controls Liver Proliferation via Interactions with C/EBP{beta}-LAP and C/EBP{beta}-LIP D. Orellana, X. Liu, G.-L. Wang, J. Jin, P. Iakova and N. A. Timchenko J. Biol. Chem., July23, 2010; 285 (30): 23444-23456. [Abstract] [Full Text] [PDF]
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Medline items on this article's topics can be found at on the following topics: Developmental Biology .. Regeneration Physiology .. Liver Religious Studies .. Death Medicine .. Alcohol Abuse Medicine .. Alcoholic Liver DiseasesMedicine .. Alcoholic Fatty Liver Updated information and services including high-resolution figures, can be found at: Additional material and information about AJP - Gastrointestinal and Liver Physiology can be found at:

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AJP - Gastrointestinaland Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 2005 by the American Physiological Society. ISSN: 0193-1857, ESSN:1522-1547. Visit our website at

Am J Physiol Gastrointest Liver Physiol 288: G1–G6, 2005; doi:10.1152/ajpgi.00376.2004.


Recent Events in Alcoholic Liver Disease V. Effects of ethanol on liver regeneration
Anna Mae Diehl
Department of Medicine, Duke University, Durham, North Carolina Diehl, Anna Mae. Recent Events in Alcoholic Liver Disease. V. Effects ofethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol 288: G1–G6, 2005; doi:10.1152/ajpgi.00376.2004.— Liver regeneration is necessary to recover from alcoholic liver injury. Herein, we review evidence that ethanol interferes with liver regeneration. Briefly, alcoholic fatty livers demonstrate increased rates of hepatocyte death. The latter provides a regenerative stimulus. However,unlike mature hepatocytes in healthy adult livers, most surviving mature hepatocytes in alcoholic fatty livers cannot replicate. Therefore, less mature cells (progenitors) must differentiate to replace dead hepatocytes. Little is known about the general mechanisms that modulate the differentiation of liver progenitors in adults. Delineation of these mechanisms and clarification of how ethanolinfluences them might suggest new therapies for alcoholic liver disease. cell senescence; progenitor cells; hepatocyte differentiation


As is true of other adult tissues, the mass of the liver is determined by the relative rates of liver cell death and proliferation. The mechanisms that balance mammalian hepatocyte death and proliferation have been studied extensively in rats andmice. For example, in healthy adult rats, the lifespan of mature hepatocytes is estimated to be 300 days. Because hepatocyte death occurs infrequently, hepatocyte proliferation is also unusual, as demonstrated by evidence that only about 1:10,000 hepatocytes are actively synthesizing DNA at any given point in time (17). To study the mechanisms that regulate hepatocyte proliferation, factors...
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