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The OSSEOTITE® Implant

The Surface That Succeeds.
Proven Performance And Predictable Outcomes

OSSEOTITE®
I M P L A N T S Y S T E M

OSSEOTITE® Implants

Proven Clinical Success
The OSSEOTITE Implant features our patented acid-etched surface that provides an effective clot/implant attachment aiding in increased platelet activation and red blood cell (RBC) agglomeration. For more than10 years, with documentation from numerous global multicenter clinical evaluations,1-8 the OSSEOTITE Surface has proven to be one of the most well-researched surfaces ever. Clinical studies on the OSSEOTITE Surface continue to document the benefits of increased Contact Osteogenesis, especially in poor-quality bone.

Enhanced OSSEOTITE SEM showing platelet activation.

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Image courtesy ofJun Y Park, The Bone Interface Group, University of Toronto.

The OSSEOTITE Implant Family

Full OSSEOTITE Tapered Certain®

OSSEOTITE Tapered Certain

Full OSSEOTITE Tapered External Hex

OSSEOTITE Tapered External Hex

OSSEOTITE Certain PREVAIL® OSSEOTITE Certain Expanded Platform PREVAIL Straight Collar

1

The OSSEOTITE® Surface And The Healing Process

Blood Clotting AndImplant Attachment
A blood clot attaches to an implant when its fibrin strands become intertwined in an implant’s microsurface features. The strength of the clot/implant attachment depends on how tightly the fibrin strands are entangled in the surface. Fibrin strands are typically submicron in diameter. Therefore, for the strongest bond, the implant surface features should create a maze of slightlylarger spaces that can tightly capture the fibrin strands. Characterized by a 1 to 3 micron peakto-peak surface created by a unique acid-etched process, the OSSEOTITE Surface features are optimally sized to entangle the fibrin strands of the blood clot.

The OSSEOTITE Surface features are optimally sized to entangle the fibrin strands.

Full OSSEOTITE Certain®

Full OSSEOTITE External HexFull OSSEOTITE XP® Certain

Full OSSEOTITE XP External Hex

OSSEOTITE Certain

OSSEOTITE External Hex

OSSEOTITE XP Certain

OSSEOTITE XP External Hex

2

The OSSEOTITE® Surface And The Healing Process

Clot Attachment Increases Contact Osteogenesis
Contact Osteogenesis Optimizes Bone Healing
Bone heals around an implant through two distinct and overlapping phenomena: DistanceOsteogenesis and Contact Osteogenesis. The rate and extent of healing around an implant is dependent on the degree of Contact Osteogenesis that occurs at the implant surface. The migration of osteogenic cells through the clot matrix causes contraction of the fibrin strands in the clot matrix, which can detach the strands from the implant, disrupting or stopping Contact Osteogenesis andOsteoconduction.9 Distance Osteogenesis

Machined Implant

Healing Bone

Existing Bone

The Stronger The Clot Is Connected To The Implant Surface, The Higher The Degree Of Contact Osteogenesis
“At the earliest stages of healing, fibrin in the blood clot binds strongly to the microtexture of the OSSEOTITE Surface. This facilitates migration of bone cells to the implant surface and results in ContactOsteogenesis.” –J.E. Davies, BSc, BDS, PhD

Contact Osteogenesis

Distance Osteogenesis –
A gradual process of bone healing inward from the edge of the osteotomy toward the implant. Bone does not grow directly on the implant surface.

Contact Osteogenesis –
The direct migration of bone-building cells through the clot matrix to the implant surface. Bone is quickly formed directly on theimplant surface.
OSSEOTITE Implant Healing Bone Existing Bone

3

The OSSEOTITE® Surface And The Healing Process

Platelet Aggregation
Platelet Activation Up-Regulates Healing Response
Osteogenic cell migration will occur through the blood clot and can be expected to be influenced by the release of cytokines and other growth factors from activated cellular components of the blood clot. In...
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