Medico
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Publicado: 16 de octubre de 2012
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E xtended report
Current evidence for the management of rheumatoid
arthritis with glucocorticoids: a systematicliterature
review informing the EULAR recommendations for the
management of rheumatoid arthritis
S L Gorter,1 Johannes W Bijlsma,2 M Cutolo,3 J Gomez-Reino,4,7 M Kouloumas,5
J S Smolen,6 R Landewé1▶
Additional data are published
online only. To view these files
please visit the journal online
(http://ard.bmj.com).
1Maastricht
University Hospital,
Maastricht, The Netherlands
HospitalUtrecht,
Utrecht, The Netherlands
3Universiy of Genova, Genova,
Italy
4University of Santiago,
Santiago, Spain
5Cyprus League Against
Rheumatism, Cyprus
6Medical University Vienna and
LainzHospital, Vienna, Austria
7Hospital Clinico Unviersitario of
Santiago, Spain
2University
Correspondence to
Dr S L Gorter, Division of
Internal Medicine, Subdivision
of Rheumatology, MaastrichtUniversity Hospital, P
Debeyelaan 25, PO Box 5800,
6202 AZ Maastricht, The
Netherlands;
s.gorter@mumc.nl
Accepted 21 April 2010
ABSTRACT
Glucocorticoids (GCs) rapidly reduce diseaseactivity
in early and advanced rheumatoid arthritis (RA). This
systematic review on behalf of the task force on
recommendations for the management of RA addresses
the efficacy of GCs in RA. A literaturesearch was
performed in Medline, Embase, the Cochrane database,
and the ACR/EULAR abstracts 2007 and 2008 on a set
of questions relating to the use of GCs in RA. Eleven
publications (includingthree Cochrane reviews comprising
33 trials) that met the criteria for detailed assessment
were found. Robust evidence that GCs are effective as
bridging therapy was obtained. The addition of GCs, toeither standard synthetic disease-modifying antirheumatic
drug (DMARD) monotherapy or combinations of synthetic
DMARDs, yields clinical benefits and inhibition of
radiographic progression that...
E xtended report
Current evidence for the management of rheumatoid
arthritis with glucocorticoids: a systematicliterature
review informing the EULAR recommendations for the
management of rheumatoid arthritis
S L Gorter,1 Johannes W Bijlsma,2 M Cutolo,3 J Gomez-Reino,4,7 M Kouloumas,5
J S Smolen,6 R Landewé1▶
Additional data are published
online only. To view these files
please visit the journal online
(http://ard.bmj.com).
1Maastricht
University Hospital,
Maastricht, The Netherlands
HospitalUtrecht,
Utrecht, The Netherlands
3Universiy of Genova, Genova,
Italy
4University of Santiago,
Santiago, Spain
5Cyprus League Against
Rheumatism, Cyprus
6Medical University Vienna and
LainzHospital, Vienna, Austria
7Hospital Clinico Unviersitario of
Santiago, Spain
2University
Correspondence to
Dr S L Gorter, Division of
Internal Medicine, Subdivision
of Rheumatology, MaastrichtUniversity Hospital, P
Debeyelaan 25, PO Box 5800,
6202 AZ Maastricht, The
Netherlands;
s.gorter@mumc.nl
Accepted 21 April 2010
ABSTRACT
Glucocorticoids (GCs) rapidly reduce diseaseactivity
in early and advanced rheumatoid arthritis (RA). This
systematic review on behalf of the task force on
recommendations for the management of RA addresses
the efficacy of GCs in RA. A literaturesearch was
performed in Medline, Embase, the Cochrane database,
and the ACR/EULAR abstracts 2007 and 2008 on a set
of questions relating to the use of GCs in RA. Eleven
publications (includingthree Cochrane reviews comprising
33 trials) that met the criteria for detailed assessment
were found. Robust evidence that GCs are effective as
bridging therapy was obtained. The addition of GCs, toeither standard synthetic disease-modifying antirheumatic
drug (DMARD) monotherapy or combinations of synthetic
DMARDs, yields clinical benefits and inhibition of
radiographic progression that...
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