Proteinas morfogeneticas de hueso en el desarrollo embrionario, referencias y metodologia

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Participacion de las proteinas morfogenicas de hueso (BMP) en la determinacion del eje dorsoventral durante el desarrollo embrionario inicial.

Luis Miguel Coronel Serrano Fundamentos de la biologia aplicada Modulo de Biologia Celular 5º B

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Referencias............................................................................ 3-10Resumenes.............................................................................11-14 Metodos.................................................................................15-16

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Rentzsch F, Anton R, Saina M et al. (2006) Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning. Dev. Biol 296, 375-387. Pizette S, Abate-Shen C & Niswander L (2001) BMP controls proximodistal outgrowth, via induction of theapical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128, 4463-4474. Tanaka M, Jokubaitis V, Wood C et al. (2009) BMP inhibition stimulates WNT-dependent generation of chondrogenic mesoderm from embryonic stem cells. Stem Cell Res 3, 126-141. Dale L & Jones CM (1999) BMP signalling in early Xenopus development. Bioessays 21, 751-760. Jasuja R, Voss N, Ge G et al.(2006) bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech. Dev 123, 548-558. Goodman SA, Albano R, Wardle FC et al. (1998) BMP1-related metalloproteinases promote the development of ventral mesoderm in early Xenopus embryos. Dev. Biol 195, 144-157. Hoppler S & Moon RT (1998) BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm.Mech. Dev 71, 119-129.

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mesoderm patterning in Xenopus. Development 124, 2325-2334. 15. Mead PE, Brivanlou IH, Kelley CM et al. (1996) BMP-4-responsive regulation of dorsalventral patterning by the homeobox protein Mix.1. Nature 382, 357-360. Larraín J, Bachiller D,Lu B et al. (2000) BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. Development 127, 821-830.

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Ahn K, Mishina Y, Hanks MC et al. (2001) BMPR-IA signaling is required for the formation 17. of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development 128, 4449-4461. 18. Saina M, Genikhovich G, Renfer E et al. (2009) BMPsand chordin regulate patterning of the directive axis in a sea anemone. Proc. Natl. Acad. Sci. U.S.A 106, 18592-18597. Clement JH, Fettes P, Knöchel S et al. (1995) Bone morphogenetic protein 2 in the early development of Xenopus laevis. Mech. Dev 52, 357-370.

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Little SC & Mullins MC (2009) Bone morphogenetic protein heterodimers assemble 20. heteromeric type I receptor complexes to...
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